The effect of fucoidin on kidney and lung injury in a rat infrarenal aortic ischemia-reperfusion model

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dc.contributor.authorGuney, Turkan
dc.contributor.authorKocman, Atacan Emre
dc.contributor.authorOzatik, Orhan
dc.contributor.authorAkyuz, Fahrettin
dc.date.accessioned2024-03-13T10:32:58Z
dc.date.available2024-03-13T10:32:58Z
dc.date.issued2022
dc.departmentİstanbul Beykent Üniversitesien_US
dc.description.abstractBackground: The aim of this study was to investigate the effects of fucoidin on rat kidney and lung in an infraaortic ishemia reperfusion model. Methods: Forty Wistar rats were randomly divided into five groups (n = 8) as sham, control (IR), before ischemia (BI), before reperfusion (BR), and before ischemia and before reperfusion (BI/BR). Rats were subjected to 120 minutes ischemia followed by 120 minutes reperfusion with application of infrarenal aortic clamping. BI received intravenous fucoidin (25 mg/kg) ten minutes before establishing ischemia and BR received ten minutes before reperfusion. BI/BR group received half equal doses of fucoidin both before ischemia (12.5 mg/kg) and reperfusion (12.5 mg/kg) periods, respectively. After sacrification blood and tissue samples were obtained for biochemical (Malondialdehyde (MDA), Nitric oxide (NO), Myeloperoxidase (MPO), Catalase (CAT), Plasma Chitotriosidase (CHIT) and serum ischemia modified albumin (IMA)) and histologic examinations. Results: MDA, NO, MPO, CAT, and IMA levels were lower in BR and BI/BR groups compared to control group (p < 0.001). Plasma CHIT levels in BR and BI/BR groups were lower than in control group (p < 0.05). According to histological examination kidney and lung injury scores were lower in BR and BI/BR groups compared to control group (p < 0.01 and p < 0.001, respectively). Conclusion: The study showed that fucoidin is effective in preventing kidney and lung injury if administered before reperfusion or both before ischemia and reperfusion. However, it has no effect if administered only before ischemia.en_US
dc.identifier.doi10.1177/0267659120982839
dc.identifier.endpage207en_US
dc.identifier.issn0267-6591
dc.identifier.issn1477-111X
dc.identifier.issue2en_US
dc.identifier.pmid33461417en_US
dc.identifier.scopus2-s2.0-85099713613en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage198en_US
dc.identifier.urihttps://doi.org/10.1177/0267659120982839
dc.identifier.urihttps://hdl.handle.net/20.500.12662/3711
dc.identifier.volume37en_US
dc.identifier.wosWOS:000628953000001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofPerfusion-Uken_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectfucoidinen_US
dc.subjectischemia reperfusionen_US
dc.subjectabdominal aortaen_US
dc.subjectkidney injuryen_US
dc.subjectlung injuryen_US
dc.subjectremote organ injuryen_US
dc.titleThe effect of fucoidin on kidney and lung injury in a rat infrarenal aortic ischemia-reperfusion modelen_US
dc.typeArticleen_US

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