The Prevalence of Periodontal Pathogenic Bacteria in Atherosclerotic Cardiovascular Disease

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dc.contributor.authorGode, Safa
dc.contributor.authorSarp, Tevhide Z.
dc.contributor.authorSaribas, Suat
dc.contributor.authorErgin, Sevgi
dc.contributor.authorKasnak, Gokhan
dc.contributor.authorDinc, Harika O.
dc.contributor.authorCaliskan, Reyhan
dc.date.accessioned2024-03-13T10:30:20Z
dc.date.available2024-03-13T10:30:20Z
dc.date.issued2020
dc.departmentİstanbul Beykent Üniversitesien_US
dc.description2nd International Human Microbiota - In Health and Diseases Congress -- APR 18-22, 2018 -- Antalya, TURKEYen_US
dc.description.abstractBackground: A possible link between periodontal pathogenic bacteria and atherosclerosis may exist based on the inflammatory mechanisms initiated by bacteria found in periodontal lesions. Our aim was to investigate the presence of DNA originating from T. denticola, C. rectus, T. forsythia, and P. gingivalis in the vascular tissue specimens obtained from patients who underwent surgery for arteriosclerotic vascular disease in this study. Methods: A total of 96 patients diagnosed with valvular heart disease due to atherosclerosis and 85 patients with advanced aortic valve stenosis due to rheumatic fever and had undergone aortic valve replacement were included as the study (PG) and the control groups (CG), respectively. Atheroma plaques and vascular tissue specimens were collected from PG and CG during cardiovascular surgical procedures. Revitalization of the lyophilized T. denticola, ATCC 35405; C. rectus, ATCC 33238; P. gingivalis, ATCC 33277 and T. forsythia, ATCC 43037 strains was performed according to the manufacturer's instructions. C. rectus, T. forsythia, and T. denticola DNA samples were analyzed using the one-step in-house PCR method. Results: In one (1.04%) and three (3.13%) out of 96 atherosclerotic PG tissue specimens, P. gingivalis and T. forsythia DNA were detected, respectively. No T. denticola or C. rectus DNA was found in the study specimens. Periodontal pathogenic bacteria were not observed in 85 CG tissue specimens. There was no statistically significant difference between PG and CG for the presence of P. gingivalis and T. forsythia DNA using Fischer's Exact test (p > 0.05). Conclusions: In conclusion, with the case-control studies on a small scale such as in our study, it is not possible to determine a causality relationship between periodontal pathogenic bacteria and formation of atherosclerosis. Periodontal pathogenic bacteria may not be the only factor that causes inflammatory diseases associated with atherosclerosis. Host response and inflammatory mechanisms may be affected by other factors such as ethnicity, dietary habits, nutritional availability, and lifestyle. Taken together, it is difficult to conclude a causal link between periodontal pathogenic bacteria and formation of atherosclerosis.en_US
dc.description.sponsorshipResearch Fundation of Istanbul University [3747]en_US
dc.description.sponsorshipThis study is supported by the Research Fundation of Istanbul University, under Project No.: 3747. We thank them for their support.en_US
dc.identifier.doi10.7754/Clin.Lab.2020.191146
dc.identifier.endpage900en_US
dc.identifier.issn1433-6510
dc.identifier.issue5en_US
dc.identifier.pmid32390375en_US
dc.identifier.scopus2-s2.0-85084389223en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage893en_US
dc.identifier.urihttps://doi.org/10.7754/Clin.Lab.2020.191146
dc.identifier.urihttps://hdl.handle.net/20.500.12662/3291
dc.identifier.volume66en_US
dc.identifier.wosWOS:000545456000023en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherClin Lab Publen_US
dc.relation.ispartofClinical Laboratoryen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectT. denticolaen_US
dc.subjectC. rectusen_US
dc.subjectP. gingivalisen_US
dc.subjectT. forsythiaen_US
dc.subjectatherosclerosisen_US
dc.titleThe Prevalence of Periodontal Pathogenic Bacteria in Atherosclerotic Cardiovascular Diseaseen_US
dc.typeConference Objecten_US

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