Investigation of Occupational Health and Safety Levels in Genetic Disease Centers in Istanbul

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dc.authorid0000-0001-7408-8533
dc.authorid0000-0002-3275-358X
dc.contributor.authorCaner, Vedat
dc.contributor.authorTanir, Ferdi
dc.date.accessioned2026-01-31T15:08:09Z
dc.date.available2026-01-31T15:08:09Z
dc.date.issued2025
dc.departmentİstanbul Beykent Üniversitesi
dc.description.abstractBackgroundGenetic disorders significantly impact public health and quality of life, necessitating precise and timely diagnosis for effective risk management and treatment. Genetic diagnostic centers (GDCs) play a critical role in this process but face numerous occupational health and safety (OHS) challenges. The classification of GDCs based solely on biosafety levels is insufficient for assessing their overall OHS conditions. This study aims to systematically evaluate OHS practices in GDCs and propose a new classification approach based on hazard dimensions.MethodsThis cross-sectional study was conducted in 15 GDCs in Istanbul, including two public and 13 private facilities with 75 employees. Data were collected through a structured survey with 49 statements covering seven hazard dimensions. Regression and correlation analyses were used to assess the impacts and interrelationships of these dimensions on risk management. Principal Component Analysis (PCA) was applied for dimensionality reduction, and the k-Nearest Neighbours (k-NN) algorithm classified laboratories into safety levels.ResultsPersonal protective equipment had the highest impact on risk management (56.3%), while physical security had the lowest (34.8%). Among the 21 identified hazard relationships, 18 were very strong and three were strong. PCA reduced the data into three primary components, explaining 81.9% of the variance. The k-NN algorithm achieved a classification accuracy of 93.33%, consolidating six hazard dimensions into three and categorizing centers into three safety levels.ConclusionThe findings emphasize the need for an updated OHS classification for GDCs beyond biosafety levels. Integrating hazard dimensions into safety assessments can improve risk management and enhance laboratory safety standards.
dc.identifier.doi10.1002/jcla.70015
dc.identifier.issn0887-8013
dc.identifier.issn1098-2825
dc.identifier.issue7
dc.identifier.pmid40143510
dc.identifier.scopus2-s2.0-105002268927
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org./10.1002/jcla.70015
dc.identifier.urihttps://hdl.handle.net/20.500.12662/10599
dc.identifier.volume39
dc.identifier.wosWOS:001464450700002
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Clinical Laboratory Analysis
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20260128
dc.subjectgenetic disease diagnostic centers
dc.subjectlaboratory hazards
dc.subjectoccupational health and safety level
dc.titleInvestigation of Occupational Health and Safety Levels in Genetic Disease Centers in Istanbul
dc.typeArticle

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