Synthesis, characterization, toxicity and in vivo imaging of lysine graft polymeric nanoparticles

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dc.contributor.authorBakan, Buket
dc.contributor.authorKayhan, Ceren Turkcan
dc.contributor.authorKarayildirim, Cinel Koksal
dc.contributor.authorDagdeviren, Melih
dc.contributor.authorGulcemal, Suleyman
dc.contributor.authorYildirim, Yeliz
dc.contributor.authorAkgol, Sinan
dc.date.accessioned2024-03-13T10:30:46Z
dc.date.available2024-03-13T10:30:46Z
dc.date.issued2019
dc.departmentİstanbul Beykent Üniversitesien_US
dc.description.abstractPolymeric nanoparticles are commonly used in several biological applications. There are limited number of studies on the toxicity and potential effectiveness of polymeric nanoparticles to need for further study on polymer science. The aim of the study was to investigate characterization, in vitro, in vivo toxicity and biological distribution of Lys-graft-p(HEMA) polymeric nanoparticle. The characterization analyses showed that Lys-graft-p(HEMA) had an average size of around 171 nm and zeta potential was -22.6 mV. The sample was recorded from 750 to 4000 cm(-1) in FTIR spectroscopy and the characteristic peaks of stretching band were observed in the spectrum. The polymeric nanoparticle did not show any cytotoxic effect on human embryonic kidney 293 healthy cell line (HEK 293, ATCC-CRL-1573) after 24 and 48 h of exposure. The nanoparticle did not cause mutation effects on Salmonella typhimurium TA 98, TA 100, TA 1535 and TA 1537 strains. In addition, it has not hemolitic activity on rabbit erythrocytes at applied concentration and no lethality was observed with single oral dose toxicity test. FITC-Lys-graft-p(HEMA) were observed on different organs such as liver, kidney, heart, lung and large intestine at 6. hours by in vivo imaging system. These results reveal that Lys-graft-p(HEMA) polymeric nanoparticles can be used as a potential drug carrier system because of its biocompatibility.en_US
dc.description.sponsorshipEge University BAP project [2015/FEN/010]en_US
dc.description.sponsorshipThe study is supported by Ege University BAP project (2015/FEN/010).en_US
dc.identifier.doi10.1007/s10965-019-1901-7
dc.identifier.issn1022-9760
dc.identifier.issn1572-8935
dc.identifier.issue10en_US
dc.identifier.scopus2-s2.0-85071939051en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1007/s10965-019-1901-7
dc.identifier.urihttps://hdl.handle.net/20.500.12662/3535
dc.identifier.volume26en_US
dc.identifier.wosWOS:000484541600001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal Of Polymer Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLys-graft-p(HEMA)en_US
dc.subjectNanoparticleen_US
dc.subjectSynthesisen_US
dc.subjectCharacterizationen_US
dc.subjectToxicityen_US
dc.subjectIn vivo imagingen_US
dc.titleSynthesis, characterization, toxicity and in vivo imaging of lysine graft polymeric nanoparticlesen_US
dc.typeArticleen_US

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