The İmpact Of Pretreatment With Simvastatin On Kidney Tissue Of Rats With Acute Sepsis

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dc.authorid123760en_US
dc.contributor.authorAydın, İrfan
dc.contributor.author., ve diğer
dc.date.accessioned2019-07-18T08:48:03Z
dc.date.available2019-07-18T08:48:03Z
dc.date.issued2017
dc.departmentİstanbul Beykent Üniversitesien_US
dc.description.abstractIt has been reported that changes in cytokine levels affect mitochondrial functions, levels of hypoxia-inducible factor ? (HIF-1?), and tissue damage during sepsis. We aimed to investigate the effects of simvastatin pretreatment on mitochondrial enzyme activities, and on levels of ghrelin, HIF-1?, and thiobarbituric acid reactive substances (TBARS) in kidney tissue during sepsis. Rats were separated into four groups, namely, control, lipopolysaccharides (LPS) (20 mg/kg), simvastatin (20 mg/kg), and simvastatin + LPS. We measured the levels of mitochondrial enzyme activities and TBARS in the kidney using spectrophotometry. The histological structure of the kidney sections was examined after staining with hematoxylin and eosin. Tumor necrosis factor ? (TNF-?), IL-10, HIF-1?, and ghrelin immunoreactivity were examined using proper antibodies. In tissue, TNF-? (p < 0.01) and HIF-1? (p < 0.05) levels were increased in the simvastatin + LPS and LPS groups. TBARS levels were higher in the LPS group than in the other groups (p < 0.01), but they were similar in the simvastatin + LPS and control groups (p > 0.05). Ghrelin immunoreactivity was lower in the LPS group (p < 0.05) and higher in the simvastatin + LPS group than in the LPS group (p < 0.01). We observed tubular damage in the sections of the LPS group. There were no differences in mitochondrial enzyme activities between the groups (p > 0.05). We observed that pretreatment of simvastatin caused favorable changes on ghrelin and TBARS levels in rats with sepsis.en_US
dc.identifier.doi10.1556/2060.104.2017.2.8
dc.identifier.issn2498-602X
dc.identifier.pmid28665194en_US
dc.identifier.scopus2-s2.0-85021785907en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1556/2060.104.2017.2.8
dc.identifier.wosWOS:000409066900006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAKADEMIAI KIADO RTtr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.subjecthypoxia-inducible factortr_TR
dc.subjectghrelintr_TR
dc.subjectkidneytr_TR
dc.subjectlipopolysaccharidestr_TR
dc.subjectsepsistr_TR
dc.subjectsimvastatintr_TR
dc.titleThe İmpact Of Pretreatment With Simvastatin On Kidney Tissue Of Rats With Acute Sepsisen_US
dc.typeArticleen_US

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