Preptin, PPAR?, and NLRP3 as inflammatory biomarkers in pediatric obesity - a pilot study

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dc.authorid0000-0002-2270-2965
dc.authorid0000-0001-7214-4407
dc.contributor.authorKahraman, Ezgi Kurkcu
dc.contributor.authorDonma, Orkide
dc.contributor.authorDonma, Mustafa Metin
dc.contributor.authorYilmaz, Ahsen
dc.contributor.authorGuzel, Savas
dc.date.accessioned2026-01-31T15:08:47Z
dc.date.available2026-01-31T15:08:47Z
dc.date.issued2025
dc.departmentİstanbul Beykent Üniversitesi
dc.description.abstractBackground Childhood obesity leads to an increased inflammatory response, which in the long term can lead to serious health problems such as metabolic syndrome, diabetes, cancer and cardiovascular disease, and may also increase the risk of obesity in adulthood. Our aim was to evaluate inflammatory markers associated with pediatric obesity in 30 healthy children (BMI between the 15th-85th percentiles) and 30 obese children (BMI > 95th percentile) and to determine the possible associations of these markers. Methods Anthropometric measurements of the children were obtained. The serum preptin, peroxisome proliferator activated receptor gamma (PPAR gamma), nod-like receptor pyrin domain-containing 3 (NLRP3), and interleukin-18 (IL-18) levels of thirty children with obesity and thirty healthy children were determined using ELISA. Results NLPR3, preptin, and PPAR gamma levels were greater obese children than in healthy children (p < 0.05). We have shown that high PPAR gamma levels may have an inhibitory effect on the inflammatory activation of NLRP3. Conclusions In our study, the changes observed in preptin, NLRP3 and PPAR gamma parameters were found to be closely associated with pediatric obesity. These molecules may play an important role in understanding the relationship between pediatric obesity and inflammation and may be used as biomarkers in determining obesity treatment and complications in future studies.
dc.description.sponsorshipResearch Fund of Istanbul University-Cerrahpasa [34574]
dc.description.sponsorshipThe present work was supported by the Research Fund of Istanbul University-Cerrahpasa. Project No: 34574.
dc.identifier.doi10.1186/s12887-025-06192-5
dc.identifier.issn1471-2431
dc.identifier.issue1
dc.identifier.pmid41121053
dc.identifier.scopus2-s2.0-105019386395
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org./10.1186/s12887-025-06192-5
dc.identifier.urihttps://hdl.handle.net/20.500.12662/10756
dc.identifier.volume25
dc.identifier.wosWOS:001598210500013
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBmc
dc.relation.ispartofBmc Pediatrics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20260128
dc.subjectChild
dc.subjectObesity
dc.subjectPreptin
dc.subjectNLRP3
dc.subjectPPAR gamma
dc.titlePreptin, PPAR?, and NLRP3 as inflammatory biomarkers in pediatric obesity - a pilot study
dc.typeArticle

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