Decreased circulating microRNA-21 and microRNA-143 are associated to pulmonary hypertension

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dc.contributor.authorDuzgun, Zekeriya
dc.contributor.authorKayikcioglu, Meral
dc.contributor.authorAktan, Cagdas
dc.contributor.authorBara, Busra
dc.contributor.authorEroglu, Zuhal
dc.contributor.authorYagmur, Burcu
dc.contributor.authorCetintas, Vildan Bozok
dc.date.accessioned2024-03-13T10:33:28Z
dc.date.available2024-03-13T10:33:28Z
dc.date.issued2023
dc.departmentİstanbul Beykent Üniversitesien_US
dc.description.abstractBackground/aim: Pulmonary arterial hypertension (PAH) is characterized by maladaptation of pulmonary vasculature which is leading to right ventricular hypertrophy and heart failure. miRNAs play a crucial role in the regulation of many diseases such as viral infection, cancer, cardiovascular diseases, and pulmonary hypertension (PH). In this study, we aimed to investigate the expression pattern of eight human plasma miRNAs (hsa-miR-21-3p, hsa-miR-143-3p, hsa-miR-138-5p, hsa-miR-145-3p, hsa-miR-190a, hsa-miR-204-3p, hsa-miR-206, hsa-miR-210-3p) in mild-to-severe PH patients and healthy controls.Materials and methods: miRNAs were extracted from the peripheral plasma of the PH patients (n: 44) and healthy individuals (n: 30) by using the miRNA Isolation Kit. cDNA was synthesized using All in-One First strand cDNA Synthesis Kit. Expression of the human plasma hsa-miR-21-3p, hsa-miR-143-3p, hsa-miR-138-5p, hsa-miR-145-3p, hsa-miR-190a, hsa-miR-204-3p, hsa-miR-206, hsa-miR-210-3p, and miRNAs were analyzed by qRT-PCR.Results: According to our results, in PH patients hsa-miR-21-3p and hsa-miR-143-3p expression levels were decreased by 4.7 and 2.3 times, respectively. No significant changes were detected in hsa-miR-138-5p, hsa-miR-145-3p, hsa-miR-190a, hsa-miR-204-3p, hsa-miR-206, and hsa-miR-210-3p expression levels between PH and control groups. In addition, considering the severity of the disease, it was observed that the decrease in miR-138, miR-143, miR-145, miR-190, mir-204, mir-206 and miR-208 expressions was significant in patients with severe PH.Conclusion: In the early diagnosis of PAH, hsa-miR-21-3p and especially hsa-miR-143-3p in peripheral plasma can be considered as potential biomarkers.en_US
dc.description.sponsorshipScientific Research Projects Coordination Unit of Ege University [16 -TIP -037]en_US
dc.description.sponsorshipAcknowledgments This work was supported by the Scientific Research Projects Coordination Unit of Ege University (project number 16 -TIP -037) .en_US
dc.identifier.doi10.55730/1300-0144.5566
dc.identifier.endpage141en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue1en_US
dc.identifier.pmid36945942en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage130en_US
dc.identifier.trdizinid1160086en_US
dc.identifier.urihttps://doi.org/10.55730/1300-0144.5566
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1160086
dc.identifier.urihttps://hdl.handle.net/20.500.12662/3953
dc.identifier.volume53en_US
dc.identifier.wosWOS:000941667500016en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technological Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal Of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPulmonary hypertensionen_US
dc.subjectmiRNAen_US
dc.subjecthsa-miR-21-3pen_US
dc.subjecthsa-miR-143-3pen_US
dc.subjectbiomarkeren_US
dc.subjectvascular remodelingen_US
dc.titleDecreased circulating microRNA-21 and microRNA-143 are associated to pulmonary hypertensionen_US
dc.typeArticleen_US

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