Effects of the oxidative stress and genetic changes in varicose vein patients

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dc.contributor.authorSaribal, Devrim
dc.contributor.authorKanber, Eyup Murat
dc.contributor.authorHocaoglu-Emre, Fatma Sinem
dc.contributor.authorAkyolcu, Mehmet C.
dc.date.accessioned2024-03-13T10:32:59Z
dc.date.available2024-03-13T10:32:59Z
dc.date.issued2019
dc.departmentİstanbul Beykent Üniversitesien_US
dc.description.abstractBackground Etiology of the varicose veins is still partly known. It has been proposed that varicose veins formation might be a cause of the oxidative stress and/or cause from genetical reasons. Method The levels of antioxidant defense system enzymes, superoxide dismutase, catalase, glutathione peroxidase, glutathione S-transferase, and an oxidative stress indicator, malondialdehyde, were measured in saphenous vein samples of varicose veins patients. Additionally, genetical polymorphism of glutathione S-transferase theta-1 has been studied. Result In this study, measurements revealed significant increase in catalase and malondialdehyde levels in the patient group, whereas superoxide dismutase and glutathione peroxidase and glutathione S-transferase enzyme activity and comparison of the null mutation frequency in the glutathione S-transferase theta-1 gene did not show a statistically significant difference. Conclusion We propose that the increase in catalase and malondialdehyde activities in our patient group may be related to each other. Increase in catalase levels, an antioxidant enzyme might be a compensatory response to the increase in malondialdehyde levels, an oxidative molecule.en_US
dc.description.sponsorshipResearch Fund of Istanbul University [2897]en_US
dc.description.sponsorshipThe author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the Research Fund of Istanbul University, project no. 2897.en_US
dc.identifier.doi10.1177/0268355518814124
dc.identifier.endpage413en_US
dc.identifier.issn0268-3555
dc.identifier.issn1758-1125
dc.identifier.issue6en_US
dc.identifier.pmid30463472en_US
dc.identifier.scopus2-s2.0-85059472545en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage406en_US
dc.identifier.urihttps://doi.org/10.1177/0268355518814124
dc.identifier.urihttps://hdl.handle.net/20.500.12662/3712
dc.identifier.volume34en_US
dc.identifier.wosWOS:000472183600006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofPhlebologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectVaricose veinsen_US
dc.subjectgreat saphenous veinen_US
dc.subjectvascular surgeryen_US
dc.titleEffects of the oxidative stress and genetic changes in varicose vein patientsen_US
dc.typeArticleen_US

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