The association between cagL and cagA, vacAs/m, babA genes in patients with gastric cancer, duodenal ulcer, and non-ulcer dyspepsia related to Helicobacter pylori

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dc.contributor.authorDemiryas, S.
dc.contributor.authorCaliskan, R.
dc.contributor.authorSaribas, S.
dc.contributor.authorAkkus, S.
dc.contributor.authorGareayaghi, N.
dc.contributor.authorKirmusaoglu, S.
dc.contributor.authorKepil, N.
dc.date.accessioned2024-03-13T10:33:42Z
dc.date.available2024-03-13T10:33:42Z
dc.date.issued2020
dc.departmentİstanbul Beykent Üniversitesien_US
dc.description.abstractIntroduction : As a component of the cag T4SS, the cagL gene is invoked in the translocation of CagA into host cells and is essential for the formation of cag PAI-associated pili between H. pylori and gastric epithelial cells. Aim : We aimed to investigate the clinical association of the cagL gene with other virulence Factors (VacA, CagA, EPIYA-C, and BabA protein) of GC, pylori strains isolated from GC, duodenal ulcer (DU), and non-ulcer dyspepsia (NUD) cases. Methods : The patient group (PC), including 47 patients (22 GC and 25 DU) and a 25 control group (CG= NUD) were included. Amplification of the H. pylori cagL, cagA, vacA, and babA2 genes and typing of EPIYA motifs were performed by PCR methods. Results : Sixty-one (84.7%) H. pylori strains were detected with cagL (93.6% in SG, 68% in CG). We detected a significant difference between SG and (1; for the presence of cagL (p=0.012) but no statistical comparison was done for (>= 2) EPIYA-C repeats In the comparison of H. pylori strains with cagA/vacAs1m1 and cagA/vacAs1m2 and babA2 for the presence of cagL we could not detect a significant difference (p=1). Conclusion : We detected a significant difference between groups for the presence of cagL genotype (p=0.012). The vacAs1m1 (OR: 2.829), genotypes increased the GC and DU risk by 2.8 times, while multiple (>= 2) EPIYA-C repeats incresed the GC and DU risk by 3.524 times. Gender (to be female) (OR: 0.454) decreased the GC and DU risk by inversly decreased in the multivariate analysis.en_US
dc.description.sponsorshipIstanbul University Research Fund [45151]en_US
dc.description.sponsorshipThis work was supported by the Istanbul University Research Fund under project number 45151.en_US
dc.identifier.endpage392en_US
dc.identifier.issn1784-3227
dc.identifier.issue3en_US
dc.identifier.pmid33094584en_US
dc.identifier.scopus2-s2.0-85094571724en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage385en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12662/4127
dc.identifier.volume83en_US
dc.identifier.wosWOS:000582321900004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherUniv Catholique Louvain-Uclen_US
dc.relation.ispartofActa Gastro-Enterologica Belgicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHelicobacter pylorien_US
dc.subjectcytotoxin-associated gene A (cagA)en_US
dc.subjectcytotoxin-associated gene L(cagL)en_US
dc.subjectvacuolating cytotoxin A (vacA)en_US
dc.titleThe association between cagL and cagA, vacAs/m, babA genes in patients with gastric cancer, duodenal ulcer, and non-ulcer dyspepsia related to Helicobacter pylorien_US
dc.typeArticleen_US

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