Endometrial injury and fertility outcome on the day of oocyte retrieval

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Bayrakol Medical Publisher

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Aim: In this study, we aimed to investigate the effect of mechanical endometrial injury, performed on the day of egg retrieval, on pregnancy rates in patients who underwent IVF/ICSI due to PCOS and planned total embryo freezing. Material and Methods: Sixty women with PCOS scheduled for total embryo freezing due to the risk of ovarian hyperstimulation syndrome were included in the study. The participants were randomly divided into two groups as treatment and control, with 30 patients in each group. For patients in both groups, standard antagonist protocol for controlled ovarian stimulation was applied. The patients in the treatment group underwent endometrial scratching with a Pipelle cannula after egg collection. The patients in the control group (sham) were reached up to the fundus with a Pipelle catheter, but scratching was not performed. The primary outcome measures of the study were beta-hCG, clinical pregnancy rates (CPR), live birth rates (LBR), and miscarriage rates. Results: There was no significant difference between the two groups in terms of the percentage of beta-hCG positive patients, clinical pregnancy and live births (p>0.05). Clinical pregnancy and live birth rates of both groups were recorded as similar. No significant difference was found between the injury group and the control group in terms of miscarriages rates. All of the pregnancies in the scratching group and control group were intrauterine localized and no ectopic pregnancy was encountered. Discussion: Injury to the endometrium on the day of egg collection does not cause a significant increase in clinical pregnancy and live birth rates.


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Mechanical Endometrial Injury, Oocyte Retrieval Day, Clinical Pregnancy, Live Birth, Miscarriage


Annals Of Clinical And Analytical Medicine

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