Venous leg symptoms in migraineurs: a potential clue on the pathophysiology of migraine

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dc.contributor.authorCuglan, Bilal
dc.contributor.authorOnalan, Aysenur
dc.contributor.authorOzturk, Selcuk
dc.contributor.authorAltuntas, Emine
dc.contributor.authorDemiral, Ahmet B.
dc.contributor.authorAtmaca, Hasan
dc.contributor.authorAltintas, Sait
dc.date.accessioned2024-03-13T10:33:09Z
dc.date.available2024-03-13T10:33:09Z
dc.date.issued2022
dc.departmentİstanbul Beykent Üniversitesien_US
dc.description.abstractBACKGROUND: Migraine is a neurovascular disorder which cerebral venous congestion might have role in pathogenesis. The objective was to assess the association between venous disease and migraine by using the Venous Insufficiency Epidemiological and Economic Study-Quality of Life/Symptoms (VEINES-QoL/Sym) questionnaire in migraineurs and non-migraineurs. METHODS: The study was designed as a non-randomized, prospective cohort study and consisted of patients diagnosed with migraine and age-, sex- matched healthy subjects without migraine. All participants were examined for the presence of chronic venous disease (CVD). VEINES-Sym questionnaire was applied to assess venous symptoms. The Migraine Disability Assessment (MIDAS) questionnaire was used to assess the severity of disease in migraineurs. RESULTS: Participants were classified into two groups as migraine-positive group (N.=130) and migraine-negative group (N.=130). Migraine patients and control group were comparable in terms of clinical status and demographic parameters. Total VEINES-Sym score was lower in patients with migraine compared to control group (34.4 +/- 8.7, 37.6 +/- 8.12, P=0.003, respectively). Additionally, there was a significant negative correlation between VEINES-Sym score and total MIDAS disability score (r=-0.33, P<0.001) and MIDAS severity levels (little or no, mild, moderate, severe) (r=-0.266, P=0.003) of the migraineurs. Logistic regression analysis revealed that VEINES-Sym score is an independent and statistically significant associate of migraine (OR=0.95, 95% CI:0.92-0.98, P=0.001). CONCLUSIONS: We have documented an independent association between migraine and VEINES-Sym score indicating possible pathophysiological link between migraine and CVD. Further studies are warranted to figure out the pathophysiological associations between migraine and venous vascular pathology and peripheral varicose vein.en_US
dc.identifier.doi10.23736/S1593-232X.22.00529-X
dc.identifier.endpage58en_US
dc.identifier.issn1593-232X
dc.identifier.issn1827-1766
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85139180367en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage52en_US
dc.identifier.urihttps://doi.org/10.23736/S1593-232X.22.00529-X
dc.identifier.urihttps://hdl.handle.net/20.500.12662/3808
dc.identifier.volume23en_US
dc.identifier.wosWOS:000923953900005en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherEdizioni Minerva Medicaen_US
dc.relation.ispartofActa Phlebologicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectVenous insufficiencyen_US
dc.subjectCardiologyen_US
dc.subjectMigraine disordersen_US
dc.titleVenous leg symptoms in migraineurs: a potential clue on the pathophysiology of migraineen_US
dc.typeArticleen_US

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