Impact of trophoectoderm biopsy for preimplantation genetic testing on serum ß-hCG levels, time of delivery and birthweight following frozen embryo transfer cycles

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dc.contributor.authorOzdamar, Ozkan
dc.contributor.authorBoynukalin, F. Kubra
dc.contributor.authorGultomruk, Meral
dc.contributor.authorYarkiner, Zalihe
dc.contributor.authorFindikli, Necati
dc.contributor.authorBahceci, Mustafa
dc.date.accessioned2024-03-13T10:35:23Z
dc.date.available2024-03-13T10:35:23Z
dc.date.issued2023
dc.departmentİstanbul Beykent Üniversitesien_US
dc.description.abstractAim: This study investigated whether trophoectoderm (TE) biopsy adversely impacts serum ss-human chorionic gonadotropin (hCG) level on the 15th day of embryo transfer (ET), delivery week and birthweight, between biopsied and unbiopsied embryo groups, in a cohort of women who delivered a singleton baby, following frozen-thawed ET. Methods: All women having had a live birth after blastocyst ET s following frozen ET cycles with preimplantation genetic testing (PGT) were included. A control group was selected among women who had a live birth following single frozen blastocyst transfer without PGT-A at the same period in our clinic Results: One hundred fifteen and 173 cycles with- and without-PGT, respectively, were included. Serum ss-hCG level on the 15th day after ET was comparable between the groups (p =.336). Average birthweight of the babies born following biopsied embryos were significantly lower (3200 vs. 3380; p =.027). Women who received trophectoderm biopsied embryos had a significantly higher probability of having a baby weighing <= 1500 g and 1500-2500 g (p =.022) or <= 2500 g (p =.008). Proportion of preterm delivery was significantly higher in the biopsy group (p =.023). However, after adjusting for potential covariates, trophectoderm biopsy did not seem to increase the risk of preterm birth (OR 1.525; 95% CI, 0,644-3.611; p =.338) Conclusions: TE biopsy does not seem to impact serum ss-hCG level on the 15th day after ET. Average birthweight is lower when a biopsied embryo was transferred. After adjusting for potential covariates, trophectoderm biopsy does not seem to increase the risk of preterm birthen_US
dc.identifier.doi10.1080/09513590.2023.2227278
dc.identifier.issn0951-3590
dc.identifier.issn1473-0766
dc.identifier.issue1en_US
dc.identifier.pmid37364607en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1080/09513590.2023.2227278
dc.identifier.urihttps://hdl.handle.net/20.500.12662/4406
dc.identifier.volume39en_US
dc.identifier.wosWOS:001020781400001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofGynecological Endocrinologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPreimplantation genetic testen_US
dc.subjecttrophoectoderm biopsyen_US
dc.subjectss-hCGen_US
dc.subjectfrozen embryo transferen_US
dc.subjectblastocysten_US
dc.subjectperinatal outcomesen_US
dc.titleImpact of trophoectoderm biopsy for preimplantation genetic testing on serum ß-hCG levels, time of delivery and birthweight following frozen embryo transfer cyclesen_US
dc.typeArticleen_US

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