Fabrication and characterization of 4D-printed graphene oxide-reinforced PLA/PCL spinal cages for minimally invasive fusion surgery

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dc.authorid0000-0001-9670-2426
dc.contributor.authorEryildiz, Meltem
dc.contributor.authorKadirhan, Ozge Altintas
dc.contributor.authorDemirci, Mehmet
dc.contributor.authorKarakus, Aleyna
dc.contributor.authorAltan, Mihrigul Eksi
dc.date.accessioned2026-01-31T15:08:13Z
dc.date.available2026-01-31T15:08:13Z
dc.date.issued2025
dc.departmentİstanbul Beykent Üniversitesi
dc.description.abstractThis study focuses on the development and characterization of 4D-printed, thermally activated polylactic acid (PLA)/polycaprolactone (PCL) spinal cages reinforced with graphene oxide (GO) for minimally invasive spinal fusion surgery. The primary objective is to fabricate biodegradable, shape memory cages that can be inserted in a compressed form and subsequently expand in situ upon thermal activation, enabling less invasive and more adaptable spinal implants. A 80:20 PLA/PCL blend was selected and reinforced with GO at varying concentrations (0.5-3 wt.%) to improve mechanical strength, thermal behavior, shape memory performance, and biodegradability. Among the formulations, 1 wt.% GO exhibited the most favorable combination of properties, achieving the highest tensile strength (23.6 MPa), compressive strength (40.7 MPa), and crystallinity (74.7%). Shape recovery tests demonstrated rapid and efficient re-expansion, especially under radiofrequency (RF) heating, which enabled uniform activation even in larger cage designs. Biodegradation studies showed progressive mass loss over 90 days, with GO accelerating degradation due to increased surface hydrophilicity, as confirmed by water contact angle measurements. Scanning electron microscopy (SEM) imaging indicated distinct changes in the microstructure with increasing GO content. The novelty of this study lies in the development of 4D-printed GO-reinforced PLA/PCL composite cages specifically tailored for minimally invasive spinal fusion. The results confirm that the proposed material and design strategy not only fulfills the key objectives of enhancing mechanical integrity, biodegradability, and shape memory functionality within a single implant platform, but also suggests strong potential for minimally invasive deployment and anatomical conformity in spinal fusion applications.
dc.description.sponsorshipTrkiye Bilimsel ve Teknolojik Arascedil;timath;rma Kurumu [123M748]; Scientific and Technological Research Council of Turkey (TUBITAK); TUBITAK
dc.description.sponsorshipThis study was supported by Scientific and Technological Research Council of Turkey (TUBITAK) under the Grant Number 123M748. The authors thank to TUBITAK for their supports.
dc.identifier.doi10.1007/s40964-025-01185-3
dc.identifier.endpage9555
dc.identifier.issn2363-9512
dc.identifier.issn2363-9520
dc.identifier.issue11
dc.identifier.scopus2-s2.0-105007333585
dc.identifier.scopusqualityQ1
dc.identifier.startpage9535
dc.identifier.urihttps://doi.org./10.1007/s40964-025-01185-3
dc.identifier.urihttps://hdl.handle.net/20.500.12662/10630
dc.identifier.volume10
dc.identifier.wosWOS:001502603200001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSpringernature
dc.relation.ispartofProgress in Additive Manufacturing
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20260128
dc.subject4D printing
dc.subjectShape memory polymers
dc.subjectPLA/PCL-graphene oxide
dc.subjectIntervertebral cages
dc.subjectSpinal fusion
dc.subjectMinimally invasive surgery
dc.titleFabrication and characterization of 4D-printed graphene oxide-reinforced PLA/PCL spinal cages for minimally invasive fusion surgery
dc.typeArticle

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