Evaluation of the effect of gluten-free diet and Mediterranean diet on autoimmune system in patients with Hashimoto's thyroiditis

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dc.contributor.authorUlker, Mutlu Tuce
dc.contributor.authorColak, Gozde Aritici
dc.contributor.authorBas, Murat
dc.contributor.authorErdem, Mustafa Genco
dc.date.accessioned2024-03-13T10:30:38Z
dc.date.available2024-03-13T10:30:38Z
dc.date.issued2024
dc.departmentİstanbul Beykent Üniversitesien_US
dc.description.abstractHashimoto's thyroiditis is an autoimmune disease in which thyroid cells are attacked through cell-and antibody-mediated immune processes. A gluten-free diet reduces antibody concentration and regulates thyroid autoimmunization. Mediterranean diet reduces oxidative stress. This study evaluates the short-term effects of Mediterranean, gluten-free, and Mediterranean gluten-free dietary patterns on thyroid function and autoantibody levels of patients. The 40 patients with Hashimoto's thyroiditis included in the study were randomly divided into four groups (defined as gluten-free, Mediterranean, Mediterranean gluten-free, and controls) for 12 weeks. Thyroid function tests, autoantibody levels, and food consumption were recorded at the beginning and end of the study. There was no statistically significant difference in TSH levels of the groups before the intervention, but a statistically significant difference was found afterward (p < 0.05). Free T-3 hormone levels showed a statistically significant difference across the groups before and after the intervention (p < 0.05). Free T-3 hormone levels increased significantly in all intervention groups after the intervention, with the highest increase in the Mediterranean group (p < 0.05). In the intervention groups, anti-TPO and anti-Tg levels decreased after the intervention; however, this difference was not significant across groups (p > 0.05). In addition, body weight, body mass index, waist and hip circumference averages decreased significantly in all intervention groups compared with controls (p < 0.05). The study achieved an increase in Free T-3 hormone levels in the intervention groups. The most marked difference was seen in the Mediterranean gluten-free diet model, which may be due to the anti-inflammatory effect of both Mediterranean and gluten-free diets and the loss of body weight as a result of the intervention.en_US
dc.identifier.doi10.1002/fsn3.3833
dc.identifier.endpage1188en_US
dc.identifier.issn2048-7177
dc.identifier.issue2en_US
dc.identifier.pmid38370054en_US
dc.identifier.scopus2-s2.0-85177434047en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1180en_US
dc.identifier.urihttps://doi.org/10.1002/fsn3.3833
dc.identifier.urihttps://hdl.handle.net/20.500.12662/3448
dc.identifier.volume12en_US
dc.identifier.wosWOS:001107486800001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofFood Science & Nutritionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectgluten-free dieten_US
dc.subjectHashimotoen_US
dc.subjectMediterranean dieten_US
dc.titleEvaluation of the effect of gluten-free diet and Mediterranean diet on autoimmune system in patients with Hashimoto's thyroiditisen_US
dc.typeArticleen_US

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