Extraction, purification of bioactive trans-resveratrol from grape pomace as factory waste, and enhancement of bioavailability through encapsulation technology

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dc.contributor.authorKaragul, Pinar
dc.contributor.authorUgras, Halil Ibrahim
dc.date.accessioned2026-01-31T15:08:17Z
dc.date.available2026-01-31T15:08:17Z
dc.date.issued2025
dc.departmentİstanbul Beykent Üniversitesi
dc.description.abstractTrans-Resveratrol is a key phenolic compound with known health benefits but suffers from low bioavailability and instability. Its encapsulation is challenging due to its polarity. In this study, trans-resveratrol was isolated, purified, and structurally characterized from grape pomace, a wine industry by-product, using LC-MS/MS, HPLC-PDA, and 1H NMR. To improve its stability and solubility, nanoencapsulation was carried out with lecithin via lyophilization. The resulting nanoparticles had sizes below 160 nm, a PDI under 0.5, and high colloidal stability as shown by zeta potential analysis. In vitro release tests in simulated gastric and intestinal fluids revealed enhanced release for the lecithin-encapsulated formulation, achieving up to 80 % in intestinal conditions, unlike free trans-resveratrol. These findings suggest that grape pomace is a valuable source of bioactive compounds and that lecithin-based nanoencapsulation offers a promising strategy to enhance the delivery and bioavailability of trans-resveratrol.
dc.identifier.doi10.1016/j.foodchem.2025.146352
dc.identifier.issn0308-8146
dc.identifier.issn1873-7072
dc.identifier.pmid41005034
dc.identifier.scopus2-s2.0-105016880424
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org./10.1016/j.foodchem.2025.146352
dc.identifier.urihttps://hdl.handle.net/20.500.12662/10649
dc.identifier.volume495
dc.identifier.wosWOS:001584405500001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Sci Ltd
dc.relation.ispartofFood Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20260128
dc.subjectExtraction
dc.subjectFlash chromatography
dc.subjectLecithin
dc.subjectTrans -resveratrol
dc.subjectGrape pomace
dc.titleExtraction, purification of bioactive trans-resveratrol from grape pomace as factory waste, and enhancement of bioavailability through encapsulation technology
dc.typeArticle

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