Effects of metformin, letrozole and atorvastatin on inflammation and apoptosis in experimental peritoneal and ovarian endometriosis in the rat

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dc.contributor.authorSapmaz, Tansel
dc.contributor.authorCoskun, Gulfidan
dc.contributor.authorSaker, Dilek
dc.contributor.authorPence, Halime Hanim
dc.contributor.authorKeles, Papatya
dc.contributor.authorHayretdag, Ceyda
dc.contributor.authorKuras, Sibel
dc.date.accessioned2024-03-13T10:35:08Z
dc.date.available2024-03-13T10:35:08Z
dc.date.issued2022
dc.departmentİstanbul Beykent Üniversitesien_US
dc.description.abstractEndometriosis is a common gynecological hurting disorder in which tissue is similar to the tissue that normally lines the inner layer of the uterus. It often causes fertility problems. Unfortunately, effective treatments are limited. Therefore it's important to explore an imperative and easily accessible treatment to alleviate the probable pathologies and preserve fertility in endometriosis. Consequently, we aimed to investigate the effects of metformin, letrozole, and atorvastatin on inflammation and apoptosis in experimentally induced ovarian and peritoneal endometriosis in rat models. In the present study, 35 rats were randomly divided into five groups. Group 1: sham-operated control group. Group 2: untreated endometriosis group. Group 3: given 100 mg/kg/day of oral metformin. Group 4: given 0.1 mg/kg/day of oral letrozole. Group 5: given 2.5 mg/kg/day of oral atorvastatin. At the end of the 28 days, we examined Ki67, Bax and Bcl-2 immunoexpressions in ovarian and peritoneal tissues, and IL-6, IL-8, and TNF-alpha levels were evaluated from the peritoneal fluid. All medical treatment groups showed a significant decrease in Ki67 expression. A significant increase in Bax expression was also observed in all samples from all medical treatment groups (other than the untreated endometriosis groups). Further, a significant decrease in Bcl-2 expression was found in all medical treatment groups. IL-6, IL-8, and TNF alpha levels were significantly lower in all medical treatment groups than in the endometriosis groups. In conclusion; Metformin, letrozole, and atorvastatin showed apoptosis induction and anti-inflammatory effects on both ovarian and peritoneal endometriosis in experimental models.en_US
dc.description.sponsorshipScientific Research Projects Grants Unit, University of Health Sciences, Istanbul, Turkey [2017/050]en_US
dc.description.sponsorshipThis study was supported by the Scientific Research Projects Grants Unit, University of Health Sciences, Istanbul, Turkey [Grant Number: 2017/050] .en_US
dc.identifier.doi10.1016/j.prp.2022.153951
dc.identifier.issn0344-0338
dc.identifier.issn1618-0631
dc.identifier.pmid35644046en_US
dc.identifier.scopus2-s2.0-85130792007en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.prp.2022.153951
dc.identifier.urihttps://hdl.handle.net/20.500.12662/4267
dc.identifier.volume235en_US
dc.identifier.wosWOS:000813351900002en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Gmbhen_US
dc.relation.ispartofPathology Research And Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEndometriosisen_US
dc.subjectMetforminen_US
dc.subjectLetrozoleen_US
dc.subjectAtorvastatinen_US
dc.subjectApoptosisen_US
dc.subjectCytokinesen_US
dc.titleEffects of metformin, letrozole and atorvastatin on inflammation and apoptosis in experimental peritoneal and ovarian endometriosis in the raten_US
dc.typeArticleen_US

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