Maternal Serum Levels of Zinc, Copper, and Thiols in Preeclampsia Patients: a Case-Control Study

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dc.contributor.authorGul, Ayse Zehra
dc.contributor.authorAtakul, Nil
dc.contributor.authorSelek, Sahabettin
dc.contributor.authorAtamer, Yildiz
dc.contributor.authorSarikaya, Ufuk
dc.contributor.authorYildiz, Tugce
dc.contributor.authorDemirel, Metin
dc.date.accessioned2024-03-13T10:30:52Z
dc.date.available2024-03-13T10:30:52Z
dc.date.issued2022
dc.departmentİstanbul Beykent Üniversitesien_US
dc.description.abstractPreeclampsia is one of the leading causes of maternal mortality-morbidity, and environmental factors act as the main driving force for the development of disease in genetically lean women. Trace element levels (zinc, copper) and thiol state (total, native thiol) may affect involved risk factors and play a role in the pathogenesis. The objective of our study is to assess trace element and thiol levels in patient and control groups. A total number of 88 pregnant women (in their third trimester) included 43 preeclampsia patients and 45 normotensive pregnant women as controls. The main findings of this study were the significantly elevated copper levels and decreased thiol levels (native and total thiols) in the patient group compared to controls (p < 0.05). Disulfide levels were not statistically different between the groups (p > 0.05). In patients, the predictive cutoff value of copper was 224 mu g/dL and was 1.19 for the copper/native thiol ratio. Zinc levels were not statistically different between the two groups. Correlation analysis revealed no relationship between zinc-copper and zinc-total thiol levels in patients, while a positive correlation was evident in controls (zinc-copper, p < 0.05, r = 0.425, and zinc-total thiol levels, p < 0.05, r = 0.642). Patients had marginally high ALT and AST values in the normal range, and a significant difference was found between the two groups (p < 0.05). According to these results, elevated copper levels and decreased thiol levels may have a value for early prediction. The mechanisms that may be responsible for the altered element and thiol status have been discussed here in the context of oxidative stress.en_US
dc.description.sponsorshipBezmialem Foundation University Scientific Research Projects Unit [6.2016/43]en_US
dc.description.sponsorshipThe research was funded by Bezmialem Foundation University Scientific Research Projects Unit (Project number: 6.2016/43).en_US
dc.identifier.doi10.1007/s12011-021-02660-y
dc.identifier.endpage472en_US
dc.identifier.issn0163-4984
dc.identifier.issn1559-0720
dc.identifier.issue2en_US
dc.identifier.pmid33704670en_US
dc.identifier.scopus2-s2.0-85102510593en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage464en_US
dc.identifier.urihttps://doi.org/10.1007/s12011-021-02660-y
dc.identifier.urihttps://hdl.handle.net/20.500.12662/3574
dc.identifier.volume200en_US
dc.identifier.wosWOS:000627670500002en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringernatureen_US
dc.relation.ispartofBiological Trace Element Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPreeclampsiaen_US
dc.subjectCopperen_US
dc.subjectZincen_US
dc.subjectThiolen_US
dc.subjectOxidative stressen_US
dc.titleMaternal Serum Levels of Zinc, Copper, and Thiols in Preeclampsia Patients: a Case-Control Studyen_US
dc.typeArticleen_US

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