Correlation of metal ions with specific brain region volumes in neurodegenerative diseases

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dc.contributor.authorMelek, Ismet Murat
dc.contributor.authorKus, Berna
dc.contributor.authorKaptan, Zulal
dc.contributor.authorPetekkaya, Emine
dc.date.accessioned2024-03-13T10:33:28Z
dc.date.available2024-03-13T10:33:28Z
dc.date.issued2023
dc.departmentİstanbul Beykent Üniversitesien_US
dc.description.abstractBackground/aim: There are reports stating that deteriorations in metal homeostasis in neurodegenerative diseases promote abnormal protein accumulation. In this study, the serum metal levels in Alzheimer's disease (AD) and Parkinson's disease (PD) and its relationship with the cortical regions of the brain were investigated. Materials and methods: The patients were divided into 3 groups consisting of the AD group, PD group, and healthy control group (n = 15 for each). The volumes of specific brain regions were measured over the participants' 3 -dimensional magnetic resonance images, and they were compared across the groups. Copper, zinc, iron, and ferritin levels in the serums were determined, and their correlations with the brain region volumes were examined. Results: The volumes of left hippocampus and right substantia nigra were lower in the AD and PD groups, while the volume of the left nucleus caudatus (CdN) and bilateral insula were lower in the AD group compared to the control group. Serum zinc levels were lower in the AD and PD groups, while the iron level was lower in the PD group in comparison to the control group. In addition, the serum ferritin level was higher in the AD group than in the control group. Serum zinc and copper levels in the AD group were positively corre-lated with the volumes of the right entorhinal cortex, thalamus, CdN, and insula. Serum zinc and copper levels in the PD group showed a negative correlation with the left nucleus accumbens (NAc), right putamen, and right insula volumes. While the serum ferritin level in the PD group displayed a positive correlation with the bilateral CdN, putamen, and NAc, as well as the right hippocampus and insula volumes, no area was detected that showed a correlation with the serum ferritin level in the AD group. Conclusion: A relationship was determined between the serum metal levels in the AD and PD groups and certain brain cortical regions that showed volumetric changes, which can be important for the early diagnosis of neurodegenerative diseases.en_US
dc.description.sponsorshipHatay Mustafa Kemal Uni- versity Scientific Research Projects Coordination Unit [21]en_US
dc.description.sponsorshipFunding This study was funded by the Hatay Mustafa Kemal Uni- versity Scientific Research Projects Coordination Unit (Project Number: 21.YL.004) .en_US
dc.identifier.doi10.55730/1300-0144.5714
dc.identifier.endpage1475en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue5en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1465en_US
dc.identifier.trdizinid1209095en_US
dc.identifier.urihttps://doi.org/10.55730/1300-0144.5714
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1209095
dc.identifier.urihttps://hdl.handle.net/20.500.12662/3954
dc.identifier.volume53en_US
dc.identifier.wosWOS:001108669900006en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technological Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal Of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAlzheimer's diseaseen_US
dc.subjectParkinson's diseaseen_US
dc.subjectmetal ionsen_US
dc.subjectvoxel-based morphometryen_US
dc.titleCorrelation of metal ions with specific brain region volumes in neurodegenerative diseasesen_US
dc.typeArticleen_US

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