Effects of salubrinal on ER stress in an experimental model of polycystic ovary syndrome

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dc.contributor.authorEmincik, Asli
dc.contributor.authorGungor, Zeynep Banu
dc.contributor.authorGuzel, Elif
dc.date.accessioned2024-03-13T10:35:21Z
dc.date.available2024-03-13T10:35:21Z
dc.date.issued2020
dc.departmentİstanbul Beykent Üniversitesien_US
dc.description.abstractThis study aimed to investigate the role of endoplasmic reticulum (ER) stress in polycystic ovary syndrome (PCOS) and the effect of salubrinal (SAL) on this role. Animals were divided into four groups as control, PCOS, PCOS+SAL and SAL. Weights and serum testosterone levels were increased in the PCOS group while serum LH and ATF4 expressions were decreased. Morphometrically, number of follicles with a diameter between 150 and 300 mu m were declined and number of follicles larger than 300 mu m as well as the percentage of cystic follicles (CFs) were increased. Immunoreactivities of GRP78 and p-eIF2 alpha were decreased, whereas oxidative stress (OS) dependent PAR expression was increased. Ultrastructurally, the PCOS group had no ER enlargement which was observed in the control group, while there were mitochondrial damage in granulosa cells (GCs). Elevated OS levels did not induce but rather decreased ER stress in GCs, and SAL injection in the PCOS model was ineffective on searched parameters. Since ER stress plays roles in certain physiological processes, we suggest that inhibitors of ER stress may not be always useful for reproductive tissues.en_US
dc.description.sponsorshipIstanbul University-Cerrahpasa [20288]en_US
dc.description.sponsorshipThis study was funded by Istanbul University-Cerrahpasa with the project number 20288.en_US
dc.identifier.doi10.1080/01913123.2020.1850963
dc.identifier.endpage435en_US
dc.identifier.issn0191-3123
dc.identifier.issn1521-0758
dc.identifier.issue4-6en_US
dc.identifier.pmid33393432en_US
dc.identifier.scopus2-s2.0-85098640172en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage422en_US
dc.identifier.urihttps://doi.org/10.1080/01913123.2020.1850963
dc.identifier.urihttps://hdl.handle.net/20.500.12662/4386
dc.identifier.volume44en_US
dc.identifier.wosWOS:000604366100001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofUltrastructural Pathologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPCOSen_US
dc.subjectsalubrinalen_US
dc.subjectER stressen_US
dc.subjectoxidative stressen_US
dc.subjectelectron microscopyen_US
dc.titleEffects of salubrinal on ER stress in an experimental model of polycystic ovary syndromeen_US
dc.typeArticleen_US

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