The Effect of Curcumin on Postmenopausal Symptoms: A Systematic Review Based on Randomized Controlled Trials

Basit Öğe Kaydı
dc.authorid0000-0003-1562-9496
dc.authorid0000-0003-0010-0012
dc.authorid0000-0001-9749-9159
dc.authorid0000-0003-0545-5680
dc.authorid0000-0002-5446-9467
dc.contributor.authorAkyakar, Buket
dc.contributor.authorSahin, Irem Nur
dc.contributor.authorAgagunduz, Duygu
dc.contributor.authorSzep, David
dc.contributor.authorBudan, Ferenc
dc.date.accessioned2026-01-31T15:09:05Z
dc.date.available2026-01-31T15:09:05Z
dc.date.issued2025
dc.departmentİstanbul Beykent Üniversitesi
dc.description.abstractMenopause is a natural and inevitable part of life for women, leading to many physical and psychological changes accompanied by declining estrogen levels. This systematic review aimed to evaluate the effect of curcumin, due to its antioxidant and anti-inflammatory properties, on postmenopausal outcomes in women. This comprehensive analysis of RCTs (randomized controlled trials) published in the last decade was selected through a search of PubMed, Wiley, Scopus, and Web of Science (PROSPERO Identifier: CRD42024549735). Study selection and data extraction were performed using exclusion and inclusion criteria according to the PICOS framework (P: Population, I: Intervention, C: Comparison, O: Outcomes, S: Study designs). Of the twelve studies that met the criteria, 11 had a low-risk bias, but reports were conflicting on serum estradiol levels, bone density markers, and vasomotor symptoms; no significant effects on physical, psychological, or sexual functions were observed. For cardiometabolic biomarkers, short-term curcumin intake showed no significant effects, while long-term interventions using bioavailable forms of curcumin showed improvements in serum fasting glucose, fasting insulin, HOMA-IR (Homeostatic Model Assessment of Insulin Resistance), and lipid parameters. There are a limited number of studies examining the effect of curcumin intake on menopause-related outcomes. While overdose has been observed in some studies attempting to restore estradiol levels, no significant effects have been observed. However, curcumin intake impacts postmenopausal symptoms (e.g., improving symptoms of osteoporosis) through its antioxidant and anti-inflammatory effects. Different forms and doses, combinations, and durations of interventions may influence outcomes. Better-designed studies are needed to understand the potential effects of curcumin intake during menopause.
dc.identifier.doi10.3390/ijms26178260
dc.identifier.issn1661-6596
dc.identifier.issn1422-0067
dc.identifier.issue17
dc.identifier.pmid40943181
dc.identifier.scopus2-s2.0-105015717141
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org./10.3390/ijms26178260
dc.identifier.urihttps://hdl.handle.net/20.500.12662/10815
dc.identifier.volume26
dc.identifier.wosWOS:001569794200001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofInternational Journal of Molecular Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20260128
dc.subjectcurcumin
dc.subjectpostmenopausal
dc.subjectsymptoms
dc.subjecthormonal balance
dc.subjectphytotherapy
dc.titleThe Effect of Curcumin on Postmenopausal Symptoms: A Systematic Review Based on Randomized Controlled Trials
dc.typeReview Article

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu