Preparation of tetracycline hydrochloride loaded chitosan/silk fibroin/ZnO antibacterial biocomposite hydrogel sponges for wound healing application

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dc.contributor.authorKaptan, Yasemin
dc.contributor.authorKaral-Yilmaz, Oksan
dc.contributor.authorIzbudak, Burcin
dc.contributor.authorGiray, Betul
dc.contributor.authorYilmaz, Bengi
dc.contributor.authorBal-Ozturk, Ayca
dc.date.accessioned2024-03-13T10:30:46Z
dc.date.available2024-03-13T10:30:46Z
dc.date.issued2023
dc.departmentİstanbul Beykent Üniversitesien_US
dc.description.abstractThree-dimensional (3D) porous biocomposite hydrogel sponges consisting of chitosan (CS), silk fibroin (SF) and ZnO nanoparticles (ZnO NPs) were prepared by the freeze-drying method. The biocomposite was also loaded with tetracycline hydrochloride (TCH) and its wound healing efficacy was investigated in an attempt to enhance healing through the release of the drug. The chemical nature, composition, thermal properties and morphology of the sponges were revealed by FTIR, TGA, and SEM/EDX, analysis. The hydrogels presented the swelling degree in the range of 650-1180% at pH 7.4; 1300-3160% at pH 5.5 and 550-920% at pH 9.0, respectively. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay demonstrated the cytocompatibility of CS/SF/ZnO hydrogels against Wharton's jelly mesenchymal stem cells (WJ-MSCs). CS/SF/ZnO-0 and CS/SF/ZnO-0.5 hydrogels exhibited no cytotoxic effect. In addition, CS/SF/ZnO hydrogels exhibited antimicrobial activity against some tested gram-positive and gram-negative bacteria. Physical immobilization of TCH in hydrogel matrix resulted in sustained release of the drug for more than 2 days at pH 7.4. The results showed that CS/SF/ ZnO-0.5 hydrogel sponge is safe, convenient and could be effective for wound healing applications.en_US
dc.identifier.doi10.1007/s10965-022-03435-2
dc.identifier.issn1022-9760
dc.identifier.issn1572-8935
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85146362170en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1007/s10965-022-03435-2
dc.identifier.urihttps://hdl.handle.net/20.500.12662/3536
dc.identifier.volume30en_US
dc.identifier.wosWOS:000909694100001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal Of Polymer Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntibacterial wound dressingen_US
dc.subjectBiocomposite hydrogel spongeen_US
dc.subjectSilk fibroinen_US
dc.subjectChitosanen_US
dc.subjectZnO nanoparticlesen_US
dc.subjectTetracycline hydrochlorideen_US
dc.subjectDrug releaseen_US
dc.titlePreparation of tetracycline hydrochloride loaded chitosan/silk fibroin/ZnO antibacterial biocomposite hydrogel sponges for wound healing applicationen_US
dc.typeArticleen_US

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