Comparison of CYP1A1 and CYP1B1 expressions in tissue biopsies obtained from with diagnosis invasive breast lobular carcinoma

Basit Öğe Kaydı
dc.contributor.authorYıldırım, İşıl
dc.contributor.authorTürk, Bilge Aydın
dc.contributor.authorOğuztüzün, Serpil
dc.contributor.authorKaygın, Pınar
dc.date.accessioned2025-03-09T18:07:43Z
dc.date.available2025-03-09T18:07:43Z
dc.date.issued2019
dc.departmentBeykent Üniversitesi
dc.description.abstractObjective: Expression of CYPs may provoke tumor development targeting activation of procarcinogens or increase in development and proliferation of breast tumor cells. Moreover, it affects the etiology of breast cancer and they may also change response to treatment. So, we aimed to compare the protein expression of CYP1A1 and CYP1B1, which are the most commonly expressed in breast cancer, which is so important.Method: Breast biopsy specimens from at least 14 invasive breast lobular carcinoma were used and they obtained from Adiyaman University Pathology Department. The protein expression of CYP1A1, CYP1B1 were determined by immunohistochemically method. Staining intensity was graded as 0 if no staining was observed, +1 if weak staining was present, +2 if moderate staining was observed, and +3 if strong staining was present.Results: Results were assessment using the total number of participants. When pathologic and histological glands are considered, for right breast, as +3 staining CYP1A1 and CYP1B1 protein expressions were found to be 83.33 % and 16.67 % respectively. In +2 staining CYP1A1 protein expressions was found to be 16.67 %, but CYPB1 not expressed. For left breast, CYP1A1 protein was strongly stained by 50 %. In account of moderate staining. In terms of moderate staining, both CYP1A1 and CYP1B1 proteins were expressed in 33.33 % percent. Besides, weak staining results to be found. CYP1A1 and CYP1B1 were found to be 16.67 % and 33.33 %, respectively. No statistically significant difference was found between CYP1A1 and CYP1B1 (P>0.05). Conclusions: CYP1A1 was expressed in all cases, whereas CYP1B1 was expressed less or not at all. These results indicate that CYP1A1 can an important marker in breast cancer cases.
dc.identifier.doi10.7197/cmj.vi.624356
dc.identifier.endpage757
dc.identifier.issn1305-0028
dc.identifier.issue4
dc.identifier.startpage754
dc.identifier.urihttps://doi.org/10.7197/cmj.vi.624356
dc.identifier.urihttps://hdl.handle.net/20.500.12662/5258
dc.identifier.volume41
dc.language.isoen
dc.publisherSivas Cumhuriyet University
dc.relation.ispartofCumhuriyet Tıp Dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_DergiPark_20250309
dc.subjectCYPA1
dc.subjectCYPA2
dc.subjectBreast cancer
dc.subjectinvasive breast lobular carcinoma
dc.subjectImmunohistochemistry
dc.titleComparison of CYP1A1 and CYP1B1 expressions in tissue biopsies obtained from with diagnosis invasive breast lobular carcinoma
dc.typeArticle

Dosyalar

Koleksiyon

DergiPark Kayıtları Koleksiyonu