Comparison of CYP1A1 and CYP1B1 expressions in tissue biopsies obtained from with diagnosis invasive breast lobular carcinoma
Küçük Resim Yok
Tarih
2019
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Sivas Cumhuriyet University
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: Expression of CYPs may provoke tumor development targeting activation of procarcinogens or increase in development and proliferation of breast tumor cells. Moreover, it affects the etiology of breast cancer and they may also change response to treatment. So, we aimed to compare the protein expression of CYP1A1 and CYP1B1, which are the most commonly expressed in breast cancer, which is so important.Method: Breast biopsy specimens from at least 14 invasive breast lobular carcinoma were used and they obtained from Adiyaman University Pathology Department. The protein expression of CYP1A1, CYP1B1 were determined by immunohistochemically method. Staining intensity was graded as 0 if no staining was observed, +1 if weak staining was present, +2 if moderate staining was observed, and +3 if strong staining was present.Results: Results were assessment using the total number of participants. When pathologic and histological glands are considered, for right breast, as +3 staining CYP1A1 and CYP1B1 protein expressions were found to be 83.33 % and 16.67 % respectively. In +2 staining CYP1A1 protein expressions was found to be 16.67 %, but CYPB1 not expressed. For left breast, CYP1A1 protein was strongly stained by 50 %. In account of moderate staining. In terms of moderate staining, both CYP1A1 and CYP1B1 proteins were expressed in 33.33 % percent. Besides, weak staining results to be found. CYP1A1 and CYP1B1 were found to be 16.67 % and 33.33 %, respectively. No statistically significant difference was found between CYP1A1 and CYP1B1 (P>0.05). Conclusions: CYP1A1 was expressed in all cases, whereas CYP1B1 was expressed less or not at all. These results indicate that CYP1A1 can an important marker in breast cancer cases.
Açıklama
Anahtar Kelimeler
CYPA1, CYPA2, Breast cancer, invasive breast lobular carcinoma, Immunohistochemistry
Kaynak
Cumhuriyet Tıp Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
41
Sayı
4
