Association of Conductive Hearing Loss with the Structural Changes in the Organ of Corti

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dc.contributor.authorEroglu, Sinan
dc.contributor.authorCevizci, Rasit
dc.contributor.authorTuran Dizdar, Handan
dc.contributor.authorTansuker, Hasan Deniz
dc.contributor.authorBulut, Erdogan
dc.contributor.authorDilci, Alper
dc.contributor.authorUstun, Selin
dc.date.accessioned2024-03-13T10:32:58Z
dc.date.available2024-03-13T10:32:58Z
dc.date.issued2021
dc.departmentİstanbul Beykent Üniversitesien_US
dc.description.abstractObjective: The aim of the study was to evaluate the association of conductive hearing loss (CHL) with the structural changes in the organ of Corti. Methods: Twenty ears of 10 healthy adult Wistar albino rats were included in the study. The right ears (n = 10) of the animals served as controls (group 1), and no surgical intervention was performed in these ears. A tympanic membrane perforation without annulus removal was performed under operative microscope on the left ears (n = 5) in 5 of 10 animals (group 2). A tympanic membrane perforation with annulus removal was performed under operative microscope on the left ears (n = 5) of the remaining 5 animals (group 3). Auditory brainstem response testing was performed in the animals before the interventions. After 3 months, the animals were sacrificed, their temporal bones were removed, and inner ears were investigated using scanning electron microscopy (SEM). The organ of Corti was evaluated from the cochlear base to apex in the modiolar axis, and the parameters were scored semiquantitatively. Results: In group 1, the pre- and post-intervention hearing thresholds were similar (p > 0.05). In group 2, a hearing decrease of at least 5 dB was encountered in all test frequencies (p > 0.05). In group 3, at the frequency range of 2-32 kHz, there was a significant hearing loss after 3 months (p < 0.01). After 3 months, the hearing thresholds in group 2 and 3 were higher than group 1 (p < 0.01). The hearing threshold in group 3 was higher than group 2 (p < 0.01). On SEM evaluation, the general cell morphology and stereocilia of the outer hair cells were preserved in all segments of the cochlea in group 1 with a mean SEM score of 0.2. There was segmental degeneration in the general cell morphology and outer hair cells in group 2 with a mean SEM score of 2.2. There was widespread degeneration in the general cell morphology and outer hair cells in group 3 with a mean SEM score of 3.2. The SEM scores of group 2 and 3 were significantly higher than group 1 (p < 0.05). The SEM scores of group 3 were significantly higher than group 2 (p < 0.05). Conclusion: CHL may be associated with an inner ear damage. The severity of damage appears to be associated with severity and duration of CHL. Early correction of CHL is advocated in order to reverse or prevent progression of the inner ear damage, which will enhance the success rates of hearing restoration surgeries. Subjective differences and compliance of the hearing aid users may be due to the impact of CHL on inner ear structures.en_US
dc.description.sponsorshipMedical Specialty Education Commission of Turkiye [2017/5]en_US
dc.description.sponsorshipStudy was supported by Medical Specialty Education Commission of Turkiye with the grant number 2017/5.en_US
dc.identifier.doi10.1159/000513871
dc.identifier.issn0301-1569
dc.identifier.issn1423-0275
dc.identifier.pmid33784680en_US
dc.identifier.scopus2-s2.0-85103576517
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1159/000513871
dc.identifier.urihttps://hdl.handle.net/20.500.12662/3706
dc.identifier.wosWOS:000635751600001
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofOrl-Journal For Oto-Rhino-Laryngology Head And Neck Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHearing lossen_US
dc.subjectScanning electron microscopyen_US
dc.subjectOrgan of Cortien_US
dc.subjectOuter hair cellen_US
dc.titleAssociation of Conductive Hearing Loss with the Structural Changes in the Organ of Cortien_US
dc.typeArticleen_US

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