Determination of modifications in rat liver due to phthalate uptake by SAM, RS, and ICP-OES

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dc.contributor.authorTanoren, Bukem
dc.contributor.authorParlatan, Ugur
dc.contributor.authorParlak, Melita
dc.contributor.authorSelcuk, Berzem
dc.contributor.authorAtes Alkan, Fatma
dc.contributor.authorPastaci Ozsobaci, Nural
dc.contributor.authorAlbeniz, Gurcan
dc.date.accessioned2024-03-13T10:35:19Z
dc.date.available2024-03-13T10:35:19Z
dc.date.issued2021
dc.departmentİstanbul Beykent Üniversitesien_US
dc.description.abstractThe use of phthalates as plasticizers has been omnipresent, especially in cosmetics and food packaging, despite the proven effects on some organs of humans and animals. Therefore, alterations in living organisms due to phthalate exposure attract the attention of many scientists. Here, we demonstrate a mechanical and chemical investigation of the mentioned effects of di(2-ethylhexyl)phthalate (DEHP) and dibutyl phthalate (DBP) on rat liver by utilizing scanning acoustic microscopy (SAM), Raman spectroscopy (RS) and inductively coupled plasma optical emission spectrometry (ICP-OES) for the first time in the literature, as far as we know. The combined analysis gives insights into the degree of modification in the tissue components and which chemicals lead to these modifications. Our study shows that the acoustic impedance values of tissues of DEHP and DBP delivered mother rats are higher than those of tissues of the control mother rat, while the acoustic impedance values of tissues of offspring rats of DEHP and DBP delivered mother rats do not differ significantly from those of tissues of the control offspring rats of the control mother rat. Besides, RS analysis shows how the incorporation of DEHP into liver tissues changes the configuration and conformation of lipids and fatty acids. ICP-OES results show increased element levels within the tissues of DEHP and DBP delivered rats. Therefore, we can say that phthalates cause modifications within the liver. This study is a preliminary effort to investigate tissues with a mechano-chemical probe.en_US
dc.description.sponsorshipMinistry of Development of Turkey [2009K120520]en_US
dc.description.sponsorshipSAM and RS studies were supported by a grant from the Ministry of Development of Turkey (Project Number: 2009K120520).en_US
dc.identifier.doi10.1039/d1ay00650a
dc.identifier.endpage2935en_US
dc.identifier.issn1759-9660
dc.identifier.issn1759-9679
dc.identifier.issue26en_US
dc.identifier.pmid34109334en_US
dc.identifier.scopus2-s2.0-85109633106en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage2926en_US
dc.identifier.urihttps://doi.org/10.1039/d1ay00650a
dc.identifier.urihttps://hdl.handle.net/20.500.12662/4353
dc.identifier.volume13en_US
dc.identifier.wosWOS:000659474100001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherRoyal Soc Chemistryen_US
dc.relation.ispartofAnalytical Methodsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleDetermination of modifications in rat liver due to phthalate uptake by SAM, RS, and ICP-OESen_US
dc.typeArticleen_US

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