Synthesis of 1,2-Dihydrofuro[3,4-d]pyrimidine Derivatives as Potential VEGFR-2 Inhibitors, and Proposed Mechanism for the 5,6-Dihydro-4H-furo[3,4-c]pyrrol-4-one
Küçük Resim Yok
Tarih
2023
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wiley-V C H Verlag Gmbh
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The fourteen novel 1,2-dihydrofuro[3,4-d]pyrimidine compounds were synthesized from 4-(2-azido-2-oxoethyl)furan-3-carbonyl azide, by the two selected Curtius rearrangement, nucleophilic addition, and intramolecular cyclization reactions. Molecular docking studies of these compounds were performed with vascular endothelial growth factors receptor-2 (VEGFR-2) tyrosine kinase (PDB ID:3WZE). Cytotoxicity studies against human prostate cancer cells (DU145), revealed that compound 8 e has cytotoxic potential. Additionally, in-silico ADME studies appeared that most of the synthesized compounds obeyed Lipinski's rule. Also, the mechanism for 5,6-dihydro-4H-furo[3,4-c]pyrrol-4-one, which occurs in the reaction of isocyanate 2 with thiols, was proposed. The azide group acts as the leaving group in this reaction.
Açıklama
Anahtar Kelimeler
Curtius Rearrengement, Intramolecular Cyclization, Lipinski Rule, Azide Elimination, Protein-Ligand Interaction
Kaynak
Chemistryselect
WoS Q Değeri
N/A
Scopus Q Değeri
Q2
Cilt
8
Sayı
17
