Oral microbial dysbiosis in patients with oral cavity cancers

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dc.authoridDemirci, Mehmet/0000-0001-9670-2426
dc.authoridUnlu, Ozge/0000-0002-5411-5925
dc.contributor.authorUnlu, Ozge
dc.contributor.authorDemirci, Mehmet
dc.contributor.authorPaksoy, Tugce
dc.contributor.authorEden, Arzu Baygul
dc.contributor.authorTansuker, Hasan Deniz
dc.contributor.authorDalmizrak, Aysegul
dc.contributor.authorAktan, Cagdas
dc.date.accessioned2025-03-09T10:49:06Z
dc.date.available2025-03-09T10:49:06Z
dc.date.issued2024
dc.departmentİstanbul Beykent Üniversitesi
dc.description.abstractObjectives The pathogenesis of oral cavity cancers is complex. We tested the hypothesis that oral microbiota dysbiosis is associated with oral cavity cancer. Materials and methods Patients with primary oral cavity cancer who met the inclusion and exclusion criteria were included in the study. Matching healthy individuals were recruited as controls. Data on socio-demographic and behavioral factors, self-reported periodontal measures and habits, and current dental status were collected using a structured questionnaire and periodontal chartings. In addition to self-reported oral health measures, each participant received a standard and detailed clinical examination. DNA was extracted from saliva samples from patients and healthy controls. Next-generation sequencing was performed by targeting V3-V4 gene regions of the 16 S rRNA with subsequent bioinformatic analyses. Results Patients with oral cavity cancers had a lower quality of oral health than healthy controls. Proteobacteria, Aggregatibacter, Haemophilus, and Neisseria decreased, while Firmicutes, Bacteroidetes, Actinobacteria, Lactobacillus, Gemella, and Fusobacteria increased in oral cancer patients. At the species level, C. durum, L. umeaens, N. subflava, A. massiliensis, and V. dispar were significantly lower, while G. haemolysans was significantly increased (p < 0.05). Major periodontopathogens associated with periodontal disease (P. gingivalis and F.nucleatum) increased 6.5- and 2.8-fold, respectively. Conclusion These data suggested that patients with oral cancer had worse oral health conditions and a distinct oral microbiome composition that is affected by personal daily habits and may be associated with the pathogenicity of the disease and interspecies interactions. Clinical relevance This paper demonstrates the link between oral bacteria and oral cancers, identifying mechanistic interactions between species of oral microbiome.
dc.description.sponsorshipIstanbul Atlas University
dc.description.sponsorshipNo Statement Available
dc.identifier.doi10.1007/s00784-024-05770-8
dc.identifier.issn1432-6981
dc.identifier.issn1436-3771
dc.identifier.issue7
dc.identifier.pmid38884817
dc.identifier.scopus2-s2.0-85196083096
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1007/s00784-024-05770-8
dc.identifier.urihttps://hdl.handle.net/20.500.12662/4726
dc.identifier.volume28
dc.identifier.wosWOS:001249690000001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer Heidelberg
dc.relation.ispartofClinical Oral Investigations
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250310
dc.subjectOral cavity cancers
dc.subjectOral microbiota
dc.subjectSaliva
dc.subjectPeriodontal disease
dc.titleOral microbial dysbiosis in patients with oral cavity cancers
dc.typeArticle

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