Effects of local anesthetics on wound healing

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dc.contributor.authorKesici, Sevgi
dc.contributor.authorKesici, Ugur
dc.contributor.authorUlusoy, Hulya
dc.contributor.authorErturkuner, Pelin
dc.contributor.authorTurkmen, Aygen
dc.contributor.authorArda, Oktay
dc.date.accessioned2024-03-13T10:30:56Z
dc.date.available2024-03-13T10:30:56Z
dc.date.issued2018
dc.departmentİstanbul Beykent Üniversitesien_US
dc.description.abstractIntroduction: Local anesthetic infiltration is used widely for post-operative analgesia in many situations. However the effects of local anesthetics on wound healing are not demonstrated clearly. This study planned to evaluate the effects of lidocaine, prilocaine, bupivacaine and levobupivacaine on wound healing, primarily on wound tensile strength and on collagen ultrastructure. Methods: This study was conducted on male Sprague Dawley rats. On days 0, 8th, 15th, and 21st, all animals were weighed and received a preincisional subcutaneous infiltration of 3 mL of a solution according the group. Control saline (C), lidocaine (L) 7 mg.kg(-1), prilocaine (P) 2 mg.kg(-1), bupivacaine (B) 2 mg.kg(-1) and levobupivacaine (LVB) 2.5 mg.kg(-1) . The infiltrations were done at the back region 1.5 cm where incision would be performed at the upper, middle and lower part along the midline, under general anesthesia. Wound tensile strengths were measured after 0.7cm x 2 cm of cutaneous and subcutaneous tissue samples were obtained vertical to incision from infiltrated regions. Tissue samples were also obtained for electron microscopic examination. Evaluations were on the 8th, 15th and 21st days after infiltration. Results: There was no difference between groups in the weights of the rats at the 0th, 8th, 15th and 21st days. The collagen maturation was no statistically different between groups at the 8th and 15th days. The maturation scores of the B and L groups at the 21st day was significantly lower than the Group C (1.40, 1.64 and 3.56; respectively). The wound tensile strength was no statistically different between groups at the 8th and 15th days but at the 21st day the Groups B and LVB had significantly lower value than Group C (5.42, 5.54 and 6.75; respectively). Conclusion: Lidocaine and prilocaine do not affect wound healing and, bupivacaine and levobupivacaine affect negatively especially at the late period. (C) 2018 Sociedade Brasileira de Anestesiologia. Published by Elsevier Editora Ltda.en_US
dc.identifier.doi10.1016/j.bjan.2018.01.016
dc.identifier.endpage382en_US
dc.identifier.issn0034-7094
dc.identifier.issn1806-907X
dc.identifier.issue4en_US
dc.identifier.pmid29884529en_US
dc.identifier.scopus2-s2.0-85048542487en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage375en_US
dc.identifier.urihttps://doi.org/10.1016/j.bjan.2018.01.016
dc.identifier.urihttps://hdl.handle.net/20.500.12662/3616
dc.identifier.volume68en_US
dc.identifier.wosWOS:000438265800007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isopoen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofRevista Brasileira De Anestesiologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectLocal anesthesiaen_US
dc.subjectWound tension strengthen_US
dc.subjectLevobupivacaineen_US
dc.subjectBupivacaineen_US
dc.subjectLidocaineen_US
dc.subjectPrilocaineen_US
dc.titleEffects of local anesthetics on wound healingen_US
dc.typeArticleen_US

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