Reduced Akkermansia muciniphila and Faecalibacterium prausnitzii levels in the gut microbiota of children with allergic asthma

Basit Öğe Kaydı
dc.contributor.authorDemirci, M.
dc.contributor.authorTokman, H. B.
dc.contributor.authorUysal, H. K.
dc.contributor.authorDemiryas, S.
dc.contributor.authorKarakullukcu, A.
dc.contributor.authorSaribas, S.
dc.contributor.authorCokugras, H.
dc.date.accessioned2024-03-13T10:30:55Z
dc.date.available2024-03-13T10:30:55Z
dc.date.issued2019
dc.departmentİstanbul Beykent Üniversitesien_US
dc.description.abstractIntroduction and objectives: The amounts of Akkermansia muciniphila and Faecalibacterium prausnitzii in gut microbiota are reduced in patients with allergic diseases compared to healthy controls. We aimed to quantify levels of A. muciniphila and F. prausnitzii amounts using real-time quantitative PCR (qPCR) in the gut microbiota of children with allergic asthma and in healthy controls. Materials and methods: In total, 92 children between the ages of three and eight who were diagnosed with asthma and 88 healthy children were included in the study and bacterial DNA was isolated from the stool samples using the stool DNA isolation Kit. qPCR assays were studied with the microbial DNA qPCR Kit for A. muciniphila and microbial DNA qPCR Kit for F. prausnitzii. Results: Both bacterial species showed a reduction in the patient group compared to healthy controls. A. muciniphila and F. prausnitzii were found to be 5.45 +/- 0.004, 6.74 +/- 0.01 and 5.71 +/- 0.002, 7.28 +/- 0.009 in the stool samples of the asthma and healthy control groups, respectively. Conclusions: F. prausnitzii and A. muciniphila may have induced anti-inflammatory cytokine IL-10 and prevented the secretion of pro-inflammatory cytokines like IL-12. These findings suggest that A. muciniphila and F. prausnitzii may suppress inflammation through its secreted metabolites. (C) 2019 SEICAP. Published by Elsevier Espana, S.L.U. All rights reserved.en_US
dc.identifier.doi10.1016/j.aller.2018.12.009
dc.identifier.endpage371en_US
dc.identifier.issn0301-0546
dc.identifier.issn1578-1267
dc.identifier.issue4en_US
dc.identifier.pmid30765132en_US
dc.identifier.scopus2-s2.0-85061247532en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage365en_US
dc.identifier.urihttps://doi.org/10.1016/j.aller.2018.12.009
dc.identifier.urihttps://hdl.handle.net/20.500.12662/3603
dc.identifier.volume47en_US
dc.identifier.wosWOS:000476694100009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Espana Sluen_US
dc.relation.ispartofAllergologia Et Immunopathologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAsthmatic childrenen_US
dc.subjectAkkermansia muciniphilaen_US
dc.subjectFaecalibacterium prausnitziien_US
dc.subjectHygiene hypothesisen_US
dc.subjectqPCRen_US
dc.titleReduced Akkermansia muciniphila and Faecalibacterium prausnitzii levels in the gut microbiota of children with allergic asthmaen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu