Risk factors for parametrial invasion in early-stage cervical cancer: Toward less radical surgery

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dc.authorid0000-0002-1632-1170
dc.contributor.authorCekic, Sebile Guler
dc.contributor.authorBulut, Mehmet
dc.contributor.authorTalmac, Merve Aldikactioglu
dc.contributor.authorAydin, Emine
dc.contributor.authorOcal, Emine Ufuk Buyukkaya
dc.contributor.authorAkca, Aysu
dc.contributor.authorNumanoglu, Ceyhun
dc.date.accessioned2026-01-31T15:09:08Z
dc.date.available2026-01-31T15:09:08Z
dc.date.issued2025
dc.departmentİstanbul Beykent Üniversitesi
dc.description.abstractObjective Radical hysterectomy with parametrectomy remains the standard treatment for early-stage cervical cancer but is associated with significant morbidity. Identifying patients at low risk for parametrial invasion is critical to support less invasive surgical strategies. Materials and Methods This retrospective study evaluated 177 patients with Federation of Gynecology and Obstetrics 2018 stage IA-IIB cervical cancer who underwent type III radical hysterectomy with lymphadenectomy between 2001 and 2020. Clinical and pathological data were analyzed to identify predictors of parametrial invasion. Results Parametrial invasion was observed in 40 patients (22.6%). These patients were significantly older (mean age 56.05 +/- 11.16 vs. 49.21 +/- 10.80 years, p=0.013), and they were more likely to be postmenopausal. Parametrial invasion was associated with larger tumor size (35.10 +/- 13.72 mm vs. 24.15 +/- 13.50 mm), greater depth of stromal invasion (>10 mm), lymphovascular space invasion (LVSI), and lymph node metastases, (pelvic and paraaortic), all p<0.01. Bivariate logistic regression identified age >= 55 years [odds ratio (OR): 3.302 95% confidence interval (CI): 1.432-7.614, p=0.005], LVSI positivity [OR: 3.952 (95% CI: 1.641-9.518, p=0.002], and stromal invasion depth >10 mm [OR: 5.326 (95% CI: 2.157-13.153, p<0.001] as independent predictors of parametrial invasion. Conclusion Age >= 55, LVSI, and deep stromal invasion are significant independent risk factors for parametrial invasion. Careful evaluation of these parameters may guide the selection of patients suitable for less radical surgery, potentially reducing morbidity without compromising oncologic outcomes.
dc.identifier.doi10.4274/tjod.galenos.2025.39969
dc.identifier.endpage245
dc.identifier.issn2149-9322
dc.identifier.issn2149-9330
dc.identifier.issue3
dc.identifier.pmid40908724
dc.identifier.scopus2-s2.0-105015410784
dc.identifier.scopusqualityQ3
dc.identifier.startpage237
dc.identifier.trdizinid1337328
dc.identifier.urihttps://doi.org./10.4274/tjod.galenos.2025.39969
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1337328
dc.identifier.urihttps://hdl.handle.net/20.500.12662/10836
dc.identifier.volume22
dc.identifier.wosWOS:001567832500001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherGalenos Publ House
dc.relation.ispartofTurkish Journal of Obstetrics And Gynecology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20260128
dc.subjectEarly-stage cervical cancer
dc.subjectparametrial invasion
dc.subjectradical hysterectomy
dc.subjectlymphovascular space invasion
dc.titleRisk factors for parametrial invasion in early-stage cervical cancer: Toward less radical surgery
dc.typeArticle

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