Investigation Of The Effect Of Chemotherapy On Cytomegalovirus Reactivity İn Patients With Solid Organ Tumors

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dc.authorid9703en_US
dc.authorid318536en_US
dc.authorid272290en_US
dc.contributor.authorSönmez, Emine
dc.contributor.authorDemirel, Aslıhan
dc.contributor.authorPilancı, Kezban Nur
dc.contributor.authorİnan, Neşe
dc.contributor.authorİris, Nur Efe
dc.contributor.authorBaygül, Arzu
dc.contributor.authorDemir, Gökhan
dc.date.accessioned2021-09-07T13:15:14Z
dc.date.available2021-09-07T13:15:14Z
dc.date.issued2021
dc.departmentİstanbul Beykent Üniversitesien_US
dc.description.abstractObjectives: Chemotherapy induces an immunosuppressive state in patients with solid organ tumors. Cytomegalovirus (CMV) reactivation as a result of immunosuppression causes a severe clinical manifestation. However, in this group, CMV infections developing due to reactivation were not adequately discussed in the literature. The aims of this study were to determine the incidence of CMV reactivation after chemotherapy, to evaluate the contribution of chemotherapy to reactivation, to determine the incidence of asymptomatic and symptomatic infections and to investigate the results of the treatment.Methods: A total of 93 patients with solid tumors were included in the study. Weekly blood samples were collected from the patients for three weeks before and after chemotherapy. Quantitative analysis of DNA was detected using CMV PCR kit (GeneProof CMV PCR kit, Bruno, Czech Republic). Diagnosis and treatment of patients were retrospectively reviewed.Results: Of the patients, 65.6% were female and 34.4% were male. The mean age was 55 ± 12 years. The most common cancer types among the patients were breast cancer in 45.2%, lung cancer in 15.1%, and colon cancer in 12.9%. The mean leukocyte count of the patients was 7,647/mm3. CMV DNA was not detected in any patient. According to this result, none of the patients had CMV reactivation after chemotherapy. Conclusions: In this study including patients with solid organ tumors with mild to moderate level of immunosuppression CMV DNA was not detected in any patient. Based on this finding no standard prophylaxis was required for CMV in this group of patients.en_US
dc.identifier.citationThe European Research Journal 2021;7(1):38-43en_US
dc.identifier.doi10.18621/eurj.573407
dc.identifier.issn2146-5193
dc.identifier.trdizinid431839en_US
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/431839
dc.identifier.urihttps://doi.org/10.18621/eurj.573407
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherSağlık Araştırmaları ve Stratejileri Derneğien_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.subjectCytomegalovirusen_US
dc.subjectSolid organ tumoren_US
dc.subjectChemotherapyen_US
dc.titleInvestigation Of The Effect Of Chemotherapy On Cytomegalovirus Reactivity İn Patients With Solid Organ Tumorsen_US
dc.typeArticleen_US

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