Impact of low-level laser therapy as an adjunct to non-surgical periodontal treatment on the levels of tissue plasminogen activator and plasminogen activator inhibitor 1 in Stage 3-4, Grade C periodontitis patients: a split-mouth, randomized control study

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dc.contributor.authorPamuk, F.
dc.contributor.authorLutfioglu, M.
dc.contributor.authorPaksoy, T.
dc.contributor.authorKoyuncuoglu, C. Z.
dc.contributor.authorPolat, N. G.
dc.contributor.authorCifcibasi, E.
dc.contributor.authorYildirim, S.
dc.date.accessioned2024-03-13T10:30:43Z
dc.date.available2024-03-13T10:30:43Z
dc.date.issued2023
dc.departmentİstanbul Beykent Üniversitesien_US
dc.description.abstractAim To investigate the effects of low-level laser therapy (LLLT) as an adjunct to non-surgical periodontal treatment (NSPT) on the plasminogen-activating system.Materials and Methods Stage 3-4 Grade C periodontitis and age-gender-matched healthy individuals participated in the split-mouth study (ClinicalTrials.gov identifier, NCT05233501). The study groups were Periodontitis/NSPT (Sham); Periodontitis/NSPT + LLLT (LLLT); Healthy (Control). Following NSPT, LLLT was applied on Days 0, 2 and 7. Clinical parameters were recorded at baseline and on Day 30. Gingival crevicular fluid (GCF) was collected at baseline, on days 7, 14, and 30; tissue-type plasminogen activator (tPA) and plasminogen activator inhibitor-1 (PAI-1) levels were measured with ELISA. Results Clinical parameters, total GCF tPA (tPAt) and PAI-1 (PAI-1t) levels significantly reduced in LLLT and Sham groups (< 0.001). GCF tPAt levels in LLLT were significantly lower (< 0.05) than Sham on Day 7. GCF tPAt levels in periodontitis groups were significantly higher than the Control at baseline, on Days 7 and 14 (< 0.01). By Day 30, both groups decreased to control levels (> 0.05). GCF PAI-1t levels were significantly lower in LLLT than the Sham on day 30 (< 0.01), comparable to healthy controls (> 0.05). Conclusion Adjunctive LLLT modulates the plasminogen activating system in severe periodontitis by altering GCF tPA and PAI-1 levels.Clinical relevanceLLLT as an adjunct to non-surgical periodontal treatment in patients with Stage 3-4 Grade C leads to reduced plasminogen activation.en_US
dc.description.sponsorshipScientific Research Fund of Beykent University [201819-BAP-05]en_US
dc.description.sponsorshipThis study was supported by the Scientific Research Fund of Beykent University (Grant/Award Number: 2018-19-BAP-05).en_US
dc.identifier.doi10.1007/s00784-023-05248-z
dc.identifier.endpage6449en_US
dc.identifier.issn1432-6981
dc.identifier.issn1436-3771
dc.identifier.issue11en_US
dc.identifier.pmid37709984en_US
dc.identifier.scopus2-s2.0-85171272785
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage6439en_US
dc.identifier.urihttps://doi.org/10.1007/s00784-023-05248-z
dc.identifier.urihttps://hdl.handle.net/20.500.12662/3515
dc.identifier.volume27en_US
dc.identifier.wosWOS:001068047300001
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofClinical Oral Investigationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLow-level laser therapyen_US
dc.subjectPeriodontitisen_US
dc.subjectTissue plasminogen activatoren_US
dc.subjectPlasminogen activator inhibitor 1en_US
dc.titleImpact of low-level laser therapy as an adjunct to non-surgical periodontal treatment on the levels of tissue plasminogen activator and plasminogen activator inhibitor 1 in Stage 3-4, Grade C periodontitis patients: a split-mouth, randomized control studyen_US
dc.typeArticleen_US

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