The effectiveness of three-dimensional (3D) PCASL MR perfusion imaging in assessing cognitive status in patients with mild cognitive impairment and Alzheimer's disease

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dc.contributor.authorComert, Sinem
dc.contributor.authorMeric, Kaan
dc.contributor.authorPekar, Recep Bilhan
dc.contributor.authorAksu, Sibel Aydin
dc.date.accessioned2024-03-13T10:33:13Z
dc.date.available2024-03-13T10:33:13Z
dc.date.issued2024
dc.departmentİstanbul Beykent Üniversitesien_US
dc.description.abstractObjective: we aimed to evaluate the relationship between CBF values obtained through PCASL MRI imaging and scores from MMSE, CDR, and CDS tests in patients diagnosed with mild cognitive impairment and Alzheimer's disease. Materials and methods: The study encompassed four groups: Control (Group 1), Mild cognitive impairment (Group 2), Moderate cognitive impairment (Group 3), and Severe cognitive impairment (Group 4). we collected CBF values derived from Pseudo Continuous Arterial Spin Labeling Manyetik Rezonans (PCASL MRI) imaging. Additionally, for patients diagnosed with mild cognitive impairment and Alzheimer's disease, scores from MMSE, CDR, and CDS tests were meticulously documented. Results: Significant differences were observed across the groups based on measures like MMSE, CDR, and regions of the brain such as the Frontal, Temporal, Hippocampus, PCC, Precuneus, Occipital, and Cerebellum (p<0.001 for each comparison). MMSE was significantly correlated with CDR (r= -0.736, p<0.001), Frontal (r= 0.464, p<0.001), Temporal (r= 0.325, p=0.017), Hippocampus (r= 0.509, p<0.001), PCC (r= 0.399, p=0.003), and Precuneus (r= 0.286, p=0.036). However, there was no significant correlation between MMSE and Occipital (p=0.113) or Cerebellum (p=0.535). Conclusions: PCASL MR imaging detects neurodegenerative changes in Alzheimer's and its milder forms, supplementing neuropsychiatric evaluations like the mini-mental test. When contrasted with FDG-PET imaging, ASL MR perfusion stands out due to its non-invasive nature, absence of radiation exposure, and cost-effectiveness. Its easy applicability further underscores its prominence as a preferred diagnostic tool in assessing dementia.en_US
dc.identifier.doi10.3306/AJHS.2024.39.01.123
dc.identifier.endpage129en_US
dc.identifier.issn1579-5853
dc.identifier.issn2255-0569
dc.identifier.issue1en_US
dc.identifier.startpage123en_US
dc.identifier.urihttps://doi.org/10.3306/AJHS.2024.39.01.123
dc.identifier.urihttps://hdl.handle.net/20.500.12662/3838
dc.identifier.volume39en_US
dc.identifier.wosWOS:001157947600017en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherReial Acad Medicina Illes Balearsen_US
dc.relation.ispartofMedicina Balearen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDementiaen_US
dc.subjectASL MR perfusionen_US
dc.subjectmini mental test scoreen_US
dc.subjectclinic dementia rateen_US
dc.subjectdisability rate by mental stateen_US
dc.titleThe effectiveness of three-dimensional (3D) PCASL MR perfusion imaging in assessing cognitive status in patients with mild cognitive impairment and Alzheimer's diseaseen_US
dc.typeArticleen_US

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