Repeated Atmospheric Pressure Alteration Effect on the Cochlea in Rats: Experimental Animal Study

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dc.contributor.authorEroglu, Sinan
dc.contributor.authorDizdar, Handan Turan
dc.contributor.authorCevizci, Rasit
dc.contributor.authorCengiz, Abdurrahman Bugra
dc.contributor.authorOgreden, Sahin
dc.contributor.authorBulut, Erdogan
dc.contributor.authorIlgezdi, Savas
dc.date.accessioned2024-03-13T10:33:13Z
dc.date.available2024-03-13T10:33:13Z
dc.date.issued2021
dc.departmentİstanbul Beykent Üniversitesien_US
dc.description.abstractOBJECTIVE: This study aimed to evaluate the effects of repeated pressure alterations on cochlear structures in rats in an attempt to understand indirectly the inner ear status of flight crew who are repeatedly exposed to pressure alterations. METHODS: There were 12 adult Wistar albino rats equally divided into 2 groups: Group 1 (controls) and Group 2 (study group). The animals in Group 2 were exposed to repeated pressure changes in a pressure cabin which is regulated by manometers. The animals in Group 1 were placed in the cabin without being exposed to pressure changes. Auditory brainstem response (ABR) testing was performed in all animals at the beginning and at the end of the study. After 12 wk the animals were sacrificed and their cochleas were investigated using scanning electron microscopy (SEM). RESULTS: In the study group, hearing decreases at 2 kHz, 4 kHz, 6 dB at 8 kHz, and 32 kHz were encountered at the end of 3 mo. On SEM evaluation of the control group, the outer hair cells (OHC) and stereocilia were normal throughout the cochlea. In the study group, there were irregularities in lateral surface connections and separations, collapse, and adhesions in the basal segment of the cochlea and partial loss of stereocilia throughout the cochlea. CONCLUSION: Repeated alterations in the atmospheric pressure can lead to damage in the inner ear with subtle or evident hearing loss. Frequent flyers like air workers may be at risk of inner ear damage, which may be considered an occupational health problem.en_US
dc.description.sponsorshipMedical Specialty Education Commission of Turkiye [2017/5]en_US
dc.description.sponsorshipThis study was supported by Medical Specialty Education Commission of Turkiye with grant number 2017/5. The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. All authors declare no conflicts of any commercial interest.en_US
dc.identifier.doi10.3357/AMHP.5732.2021
dc.identifier.endpage555en_US
dc.identifier.issn2375-6314
dc.identifier.issn2375-6322
dc.identifier.issue7en_US
dc.identifier.pmid34503628en_US
dc.identifier.scopus2-s2.0-85115931206en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage550en_US
dc.identifier.urihttps://doi.org/10.3357/AMHP.5732.2021
dc.identifier.urihttps://hdl.handle.net/20.500.12662/3839
dc.identifier.volume92en_US
dc.identifier.wosWOS:000697005800003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAerospace Medical Assocen_US
dc.relation.ispartofAerospace Medicine And Human Performanceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectinner earen_US
dc.subjectbarotraumaen_US
dc.subjectflighten_US
dc.subjectaltitudeen_US
dc.titleRepeated Atmospheric Pressure Alteration Effect on the Cochlea in Rats: Experimental Animal Studyen_US
dc.typeArticleen_US

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