The Association Between Cagl And Caga, Vacas-M, Baba Genes İn Patients With Gastric Cancer, Duodenal Ulcer, And Non-Ulcer Dyspepsia Related To Helicobacter Pylori
| dc.authorid | 201432 | en_US |
| dc.authorid | 243533 | en_US |
| dc.contributor.author | Bal, Kadir | |
| dc.contributor.author | Erzin, Yusuf Ziya | |
| dc.contributor.author | Demirci, Mehmet | |
| dc.contributor.author | ;, ve diğerleri | |
| dc.date.accessioned | 2021-01-27T10:21:03Z | |
| dc.date.available | 2021-01-27T10:21:03Z | |
| dc.date.issued | 2020 | |
| dc.department | İstanbul Beykent Üniversitesi | en_US |
| dc.description.abstract | Introduction: As a component of the cag T4SS, the cagL gene is involved in the translocation of CagA into host cells and is essential for the formation of cag PAI-associated pili between H. pylori and gastric epithelial cells. Aim: We aimed to investigate the clinical association of the cagL gene with other virulence factors (VacA, CagA, EPIYA-C, and BabA protein) of H. pylori strains isolated from GC, duodenal ulcer (DU), and non-ulcer dyspepsia (NUD) cases. Methods: The patient group (PG), including 47 patients (22 GC and 25 DU) and a 25 control group (CG= NUD) were included. Amplification of the H. pylori cagL, cagA, vacA, and babA2 genes and typing of EPIYA motifs were performed by PCR methods. Results: Sixty-one (84.7%) H. pylori strains were detected with cagL (93.6% in SG, 68% in CG). We detected a significant difference between SG and CG for the presence of cagL (p=0.012) but no statistical comparison was done for (?2) EPIYA-C repeats In the comparison of H. pylori strains with cagA/vacAs1m1 and cagA/ vacAs1m2 and babA2 for the presence of cagL, we could not detect a significant difference (p=1). Conclusion: We detected a significant difference between groups for the presence of cagL genotype (p=0.012). The vacAs1m1 (OR: 2.829), genotypes increased the GC and DU risk by 2.8 times, while multiple (?2) EPIYA-C repeats incresed the GC and DU risk by 3.524 times. Gender (to be female) (OR: 0.454) decreased the GC and DU risk by inversly decreased in the multivariate analysis. | en_US |
| dc.identifier.citation | Acta Gastro-Enterologica Belgica, Vol. 83, July-September 2020 | en_US |
| dc.identifier.issn | 1784-3227 | |
| dc.language.iso | en | en_US |
| dc.publisher | Universa Press, Wetteren, Belgium | en_US |
| dc.relation.publicationcategory | Makale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| dc.subject | Helicobacter pylori | en_US |
| dc.subject | Cytotoxin-associated gene A (cagA) | en_US |
| dc.subject | Cytotoxin-associated gene L (cagL) | en_US |
| dc.subject | Vacuolating cytotoxin A (vacA) | en_US |
| dc.title | The Association Between Cagl And Caga, Vacas-M, Baba Genes İn Patients With Gastric Cancer, Duodenal Ulcer, And Non-Ulcer Dyspepsia Related To Helicobacter Pylori | en_US |
| dc.type | Article | en_US |
