Optimized Multifunctional Chitosan/Gelatin Nanocarriers for Sustained Release of Cinnamon Essential Oil and Microbial Control

Basit Öğe Kaydı
dc.authorid0000-0002-8046-685X
dc.contributor.authorTuran, Rabia
dc.contributor.authorAydin, Yasar Andelib
dc.date.accessioned2026-01-31T15:08:08Z
dc.date.available2026-01-31T15:08:08Z
dc.date.issued2025
dc.departmentİstanbul Beykent Üniversitesi
dc.description.abstractNanoparticulate carrier systems composed of chitosan and chitosan/gelatin blends encapsulating Cinnamomum zeylanicum essential oil were developed and optimized using ionic gelation. Process parameters, including crosslinker concentration, surfactant type, polymer/oil ratio, mixing speed, and chitosan/gelatin ratio, were systematically evaluated. Chitosan-only carriers achieved 25.18% +/- 0.01% encapsulation efficiency and 30.19 +/- 0.01 mg/g oil retention, while gelatin incorporation enhanced performance to 80.89% +/- 0.07% efficiency and 78.89 +/- 0.03 mg/g retention. Fourier transform infrared spectroscopy and thermogravimetric analysis confirmed successful oil encapsulation, while scanning electron microscopy revealed spherical nanocapsules (48.48-75.45 nm), with size increasing alongside gelatin and oil content. In vitro release studies demonstrated up to 85% oil release over 4 days, with faster release in gelatin-containing systems. Antimicrobial efficacy was evidenced by 6 days of microbial growth inhibition on strawberries. Cytotoxicity assessment using the MTT assay on L929 fibroblasts confirmed the proliferative effect and the absence of cytotoxicity of the nanocarrier system. Nanoparticles retained over 80% of their oil load after 90 days of storage at -20 degrees C, highlighting their potential for sustained delivery of essential oils.
dc.identifier.doi10.1002/app.70177
dc.identifier.issn0021-8995
dc.identifier.issn1097-4628
dc.identifier.scopus2-s2.0-105024952869
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org./10.1002/app.70177
dc.identifier.urihttps://hdl.handle.net/20.500.12662/10588
dc.identifier.wosWOS:001639425400001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Applied Polymer Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20260128
dc.subjectbiomaterials
dc.subjectnanocrystals
dc.subjectnanoparticles
dc.subjectnanostructured polymers
dc.subjectnanowires
dc.subjectpackaging
dc.subjectsynthesis and processing techniques
dc.titleOptimized Multifunctional Chitosan/Gelatin Nanocarriers for Sustained Release of Cinnamon Essential Oil and Microbial Control
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu