In-Vitro Bioactivity Investigation of Sol-Gel Derived Alumina-Bovine Hydroxyapatite (BHA) Composite Powders

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dc.contributor.authorYelten, Azade
dc.contributor.authorKaral-Yilmaz, Oksan
dc.contributor.authorAkguner, Zeynep Puren
dc.contributor.authorBal-Ozturk, Ayca
dc.contributor.authorYilmaz, Suat
dc.date.accessioned2024-03-13T10:33:17Z
dc.date.available2024-03-13T10:33:17Z
dc.date.issued2020
dc.departmentİstanbul Beykent Üniversitesien_US
dc.description.abstractAlumina (alpha-Al2O3) and hydroxyapatite (HA, Ca-10(PO4)(6)(OH)(2)) are well-known for being clinically successful bioceramic materials. In this work, in-vitro biological characterization of the sol-gel alumina-bovine hydroxyapatite composite powders was realized. Alumina powders were synthesized through the sol-gel process. First, boehmite (AlOOH) sol was prepared utilizing aluminium isopropoxide (Al(OC3H7)(3), AIP) as the starting precursor. Bovine hydroxyapatite (BHA) powders, which can be defined as naturally derived calcium phosphate powders were added as 10, 20, 30, and 50% wt. of AIP to each AlOOH sol. Homogeneous dispersion of the BHA powders in the AlOOH sol was managed due to employing Na-alginate as a kind of thickener. Gelation of the AlOOH-BHA mixtures was carried out at 110 degrees C for 3h. After drying, AlOOH-BHA mixtures were heat-treated at 1300 degrees C for 2h. Chemical, microstructural, thermal, and physical properties of the precursors/process products were characterized with X-Ray Diffraction (XRD), Fourier Transform Infrared Spectroscopy (FT-IR), X-Ray Fluorescence Spectroscopy (XRF), Differential Thermal Analysis (DTA), and Scanning Electron Microscopy - Energy Dispersive Spectroscopy (SEM-EDS) analyses. Indirect MTT assay was done to evaluate the biocompatibility of the Al2O3-BHA based biocomposite extracts using the L929 cell line. It is found that all Al2O3-BHA composite extracts with varying doses of 25% and 50% had no negative effect on the cell viability. In addition, % cell viability decreased with the increasing of the extract concentration. It can be concluded that the prepared Al2O3-BHA composites can be a good candidate for biomedical applications.en_US
dc.description.sponsorshipScientific Research Project Coordination Unit of Istanbul University [4201]en_US
dc.description.sponsorshipThis work was supported by Scientific Research Project Coordination Unit of Istanbul University [grant number 4201].en_US
dc.identifier.doi10.35378/gujs.541345
dc.identifier.endpage700en_US
dc.identifier.issn2147-1762
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85097814668en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage690en_US
dc.identifier.trdizinid423125en_US
dc.identifier.urihttps://doi.org/10.35378/gujs.541345
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/423125
dc.identifier.urihttps://hdl.handle.net/20.500.12662/3859
dc.identifier.volume33en_US
dc.identifier.wosWOS:000606397400003en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherGazi Univen_US
dc.relation.ispartofGazi University Journal Of Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAluminaen_US
dc.subjectBovine Hydroxyapatiteen_US
dc.subjectSol-Gel Methoden_US
dc.subjectBiocompositesen_US
dc.subjectIn-Vitro Bioactivityen_US
dc.titleIn-Vitro Bioactivity Investigation of Sol-Gel Derived Alumina-Bovine Hydroxyapatite (BHA) Composite Powdersen_US
dc.typeArticleen_US

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