Ferric Carboxymaltose Versus Ferrous Glycine Sulfate for Treatment of Iron Deficiency Anemia and Their Effect on Vitamin B12 and Folic Acid: A Retrospective Study

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dc.authorid252295en_US
dc.contributor.authorErdem, Mustafa Genco
dc.date.accessioned2023-02-01T12:17:49Z
dc.date.available2023-02-01T12:17:49Z
dc.date.issued2022
dc.departmentİstanbul Beykent Üniversitesien_US
dc.description.abstractAim Anemia is a major public health problem, affecting about one-third of the world's population, and is most commonly caused by iron deficiency. Iron deficiency anemia requires oral or intravenous iron replacement therapy. The purpose of this study was to assess the change in several hematological parameters, vitamin B12, and folic acid from baseline to the first month of follow-up following therapy with oral ferrous glycine sulfate or intravenous ferric carboxymaltose. Methods: All patients who received oral ferrous glycine sulfate or intravenous ferric carboxymaltose for the treatment of iron deficiency anemia between January 1, 2016, and December 31, 2018, were included in the trial. Along with age and gender information, values of hemoglobin, ferritin, transferrin saturation, mean corpuscular volume, vitamin B12, and folic acid were derived from patients’ records at the beginning of treatment and first month follow-up. Results: Laboratory values obtained after treatment showed statistically significant improvement in both groups (intra group, p<0.001). When the percentage of change between groups was compared: Percentage-based increases in hemoglobin, mean corpuscular volume, transferrin saturation and ferritin values were significantly higher in the ferric carboxymaltose group (p<0.001). The percentage decrease in vitamin B12 and folic acid values was higher in the ferric carboxymaltose group (p=0.005 and p=0.01, respectively) when compared with oral ferrous glycine sulfate group. Conclusions: According to the findings of our study, iron deficiency anemia can be treated very successfully using ferric carboxymaltose; however, it should be remembered that concurrent supplementation of elements such vitamin B12 and folic acid is necessary for the appropriate progression of erythropoiesis.en_US
dc.identifier.doi10.25000/acem.1203980
dc.identifier.issn2146-9229
dc.identifier.trdizinid1145290en_US
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1145290
dc.identifier.urihttps://doi.org/10.25000/acem.1203980
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherMustafa Hasbahçecien_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.subjectFerric carboxymaltoseen_US
dc.subjectFerritinen_US
dc.subjectFolic aciden_US
dc.subjectIronen_US
dc.subjectIron deficiency anemiaen_US
dc.subjectVitamin B12en_US
dc.titleFerric Carboxymaltose Versus Ferrous Glycine Sulfate for Treatment of Iron Deficiency Anemia and Their Effect on Vitamin B12 and Folic Acid: A Retrospective Studyen_US
dc.typeArticleen_US

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