Biomimetic design and fabrication of thermally induced radial gradient shape memory scaffolds using fused deposition modeling (FDM) for bone tissue engineering

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dc.authoridEryildiz, Meltem/0000-0002-2683-560X
dc.contributor.authorEryildiz, Meltem
dc.date.accessioned2025-03-09T10:48:45Z
dc.date.available2025-03-09T10:48:45Z
dc.date.issued2025
dc.departmentİstanbul Beykent Üniversitesi
dc.description.abstractBone defects pose a significant challenge, often exceeding natural healing capabilities. This study explores the potential of thermally induced radial gradient shape memory (RGSM) scaffolds for minimally invasive bone repair. Inspired by the natural porosity gradient of bone, these scaffolds feature a high-porosity inner zone that mimics cancellous bone and a low-porosity outer zone that resembles cortical bone. When the relationship between porosity and key properties was investigated, it was found that lower-porosity RGSM scaffolds exhibited higher compressive strength but experienced higher residual strain and lower shape recovery ratio compared to their higher-porosity counterparts. Despite this trade-off, the gradient design successfully mimicked the natural bone structure, potentially enhancing osseointegration and bone regeneration. These results demonstrate the feasibility of RGSM scaffolds for bone tissue engineering. This holds promise for advancing minimally invasive surgical techniques and improving the treatment of bone defects.
dc.identifier.doi10.1177/14644207241245335
dc.identifier.endpage70
dc.identifier.issn1464-4207
dc.identifier.issn2041-3076
dc.identifier.issue1
dc.identifier.scopus2-s2.0-85189615285
dc.identifier.scopusqualityQ2
dc.identifier.startpage61
dc.identifier.urihttps://doi.org/10.1177/14644207241245335
dc.identifier.urihttps://hdl.handle.net/20.500.12662/4658
dc.identifier.volume239
dc.identifier.wosWOS:001196094100001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorEryildiz, Meltem
dc.language.isoen
dc.publisherSage Publications Ltd
dc.relation.ispartofProceedings of The Institution of Mechanical Engineers Part L-Journal of Materials-Design and Applications
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250310
dc.subjectRadial gradient scaffolds
dc.subjectfused deposition modeling
dc.subjectfour-dimensional (4D) printing
dc.subjectshape memory behavior
dc.subjectpolylactic acid (PLA)
dc.subjecttissue engineering
dc.titleBiomimetic design and fabrication of thermally induced radial gradient shape memory scaffolds using fused deposition modeling (FDM) for bone tissue engineering
dc.typeArticle

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