Exercise modulates local inflammation and tissue loss in experimental periodontitis: A histomorphometric and immunohistochemical study in ra

Basit Öğe Kaydı
dc.authorid0000-0002-3711-6520
dc.authorid0000-0003-2744-4763
dc.authorid0000-0002-2552-5159
dc.contributor.authorZehra, Gumrukcuoglu
dc.contributor.authorCetinkaya, Burcu Ozkan
dc.contributor.authorOzer, Ferda Pamuk
dc.contributor.authorInal, Sinem
dc.contributor.authorBayrakdar, Sevda Kurt
dc.contributor.authorKaya, Muhammed Taha
dc.date.accessioned2026-01-31T15:08:16Z
dc.date.available2026-01-31T15:08:16Z
dc.date.issued2026
dc.departmentİstanbul Beykent Üniversitesi
dc.description.abstractObjective This study aimed to investigate the effects of resistance exercise on the progression of periodontal disease in rats, focusing on alveolar bone loss, attachment loss, and local inflammatory and bone metabolic markers. Materials and methods Forty male Wistar albino rats were allocated into four experimental groups in a 2 x 2 factorial design: G1 or G2 and G3 or G4. The exercise protocol consisted of progressive swimming sessions over eight weeks, with resistance provided by weights tied to the animals. In the final week, MBT was performed, and rats were sacrificed for histomorphometric and immunohistochemical analysis. Results The values for alveolar bone loss and attachment loss were significantly lower in the exercised groups compared to both the G1 and G2 groups (p < 0.001). Among the rats with periodontitis, TNF-alpha expression was significantly lower in the exercised group (p = 0.002), whereas IL-10 levels showed no significant differences (p > 0.005). RANKL expression was elevated in G2 (p = 0.039), with no significant variation in OPG among groups. In MBT, G2 showed significantly higher values compared to G1 and G3 (p = 0.004). G4 displayed intermediate values, higher than G3 but lower than G2, without statistical significance (p > 0.005). Conclusion Physical exercise reduced TNF-alpha levels in the presence of periodontitis and increased IL-10, although the latter change was not statistically significant. Exercise also contributed to a decrease in RANKL/OPG expression, suggesting a protective effect on alveolar bone resorption. MBT findings further indicate that exercise may alleviate periodontitis-associated behavioral alterations, supporting its potential role as an adjunctive therapy in managing periodontitis.
dc.description.sponsorshipOndokuz Mayimath;s University Scientific Research Projects Commission [DIS.1904.19.008]; Beykent University Scientific Research Project [2019-20-BAP-03]
dc.description.sponsorshipThis study was funded by the Ondokuz May & imath;s University Scientific Research Projects Commission under project number PYO. DIS.1904.19.008 and by Beykent University Scientific Research Project under project number 2019-20-BAP-03.
dc.identifier.doi10.1016/j.archoralbio.2025.106435
dc.identifier.issn0003-9969
dc.identifier.issn1879-1506
dc.identifier.pmid41138342
dc.identifier.scopus2-s2.0-105019396634
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org./10.1016/j.archoralbio.2025.106435
dc.identifier.urihttps://hdl.handle.net/20.500.12662/10641
dc.identifier.volume181
dc.identifier.wosWOS:001608026600002
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherPergamon-Elsevier Science Ltd
dc.relation.ispartofArchives of Oral Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20260128
dc.subjectPhysical exercise
dc.subjectPeriodontitis
dc.subjectHistomorphometry
dc.subjectImmunohistochemistry
dc.subjectTNF-alpha
dc.subjectRANKL
dc.subjectIL-10
dc.subjectOPG
dc.titleExercise modulates local inflammation and tissue loss in experimental periodontitis: A histomorphometric and immunohistochemical study in ra
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu