Association of the sEH Gene Promoter Polymorphisms And Haplotypes With Preeclampsia

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dc.authorid260725en_US
dc.authorid101987en_US
dc.authorid109356en_US
dc.authorid131261en_US
dc.contributor.authorAktan, Çağdaş
dc.contributor.authorSarı, İsmail
dc.contributor.authorÖkten, Hatice
dc.contributor.authorCihan, Esra
dc.date.accessioned2021-01-27T10:20:43Z
dc.date.available2021-01-27T10:20:43Z
dc.date.issued2020
dc.departmentİstanbul Beykent Üniversitesien_US
dc.description.abstractBackground The epoxyeicosatrienoic acids (EETs) have antihypertensive, anti-inflammatory, and organ protective properties and their circulation levels are related to hypertension, diabetes mellitus, cardiovascular diseases, and preeclampsia. Soluble epoxide hydrolase (sEH) catalyses the degradation of EETs to less biologically active dihydroxyeicosatrienoic acids. Here, we sequenced the promoter region of EPHX2 to investigate the association between promoter sequence alterations that we thought to affect the expression levels of the enzyme and preeclampsia (PE). Methods Nucleotide sequencing of the promoter region of the EPHX2, spanning from position -671 to +30, was performed on 100 pregnant women with PE and, 20 or more weeks pregnant normotensive, healthy women (n=100). Results Pregnant women who carry rs4149235, rs4149232, rs73227309, and rs62504268 polymorphisms have 4.4, 2.4, 2.3, and 2.8 times significantly increased risk of PE, respectively. CCGG (OR: 3.11; 95% CI: 1.12-8.62) and CCCA (OR: 0.45; 95% CI: 0.36-0.55) haplotypes were associated with an increased and decreased risk of PE, respectively. Conclusions Four SNPs (rs4149232, rs4149235, rs73227309, and rs62504268) in the promoter region of the EPHX2, and CCGG and CCCA haplotypes of these 4 SNPs were significantly associated with PE. These SNPs in the promoter region may affect sEH expression and thus enzyme activity and may play a role in PE pathogenesis by causing individual differences in EET levels. However, future studies are needed to confirm our findings and examine the effect of these SNPs on the sEH expression and/or enzyme activity.en_US
dc.identifier.citationJ Med Biochem. 2020 Oct 2; 39(4): 428-435.en_US
dc.identifier.doi10.5937/jomb0-27745.
dc.identifier.issn2587-2362
dc.identifier.urihttps://doi.org/10.5937/jomb0-27745.
dc.language.isoenen_US
dc.publisherKare Publishingen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.subjectEpoxyeicosatrienoic acidsen_US
dc.subjectPreeclampsiaen_US
dc.subjectSoluble epoxide hydrolaseen_US
dc.subjectPolymorphismen_US
dc.subjectGene promoteren_US
dc.titleAssociation of the sEH Gene Promoter Polymorphisms And Haplotypes With Preeclampsiaen_US
dc.typeArticleen_US

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