The therapeutic role of Aronia melanocarpa on cyclophosphamide-induced premature ovarian failure

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dc.contributor.authorCelik, Huemeyra
dc.contributor.authorKara, Sinem
dc.contributor.authorBozat, Bihter Gokce
dc.contributor.authorUluc, Firdevs
dc.contributor.authorCetinkaya, Ayhan
dc.contributor.authorFirat, Tulin
dc.date.accessioned2025-03-09T10:49:09Z
dc.date.available2025-03-09T10:49:09Z
dc.date.issued2024
dc.departmentİstanbul Beykent Üniversitesi
dc.description.abstractThe purpose of the study was to evaluate the effects of Aronia melanocarpa (A. melanocarpa) extract on ovarian cell apoptosis, vascularization, and follicle reserve in the premature ovarian failure (POF) induced by cyclophosphamide (CYC). After creating a premature ovarian failure model with 100 mg/kg CYC, A. melanocarpa was given to Wistar albino female rats by gavage 15 times every other day (200 mg/kg).Vaginal smears were taken to evaluate the estrus cycles before, during and at the end of the experiment. Histological ovarian follicle count was performed by examining the ovaries with Hematoxylin&Eosin staining. Immunohistochemical evaluation of apoptosis markers of caspase-3 (cas-3), caspase-9 (cas-9) and vascular endothelial growth factor (VEGF) was performed. A. melanocarpa reregulated the estrus cycles in a similar way to the controls by reducing cas-3 and cas-9 in ovarian cells and increasing the number of ovarian cells. While CYC disrupted ovarian vascularization, A. melanocarpa contributed to ovarian reserve by increasing VEGF immunopositivity. In chemotherapy-induced POF, A. melanocarpa extract increases ovarian reserve by providing vascularization, decreasing apoptosis and providing cycle control in female rats.
dc.identifier.endpage2136
dc.identifier.issn2630-6344
dc.identifier.issue6
dc.identifier.scopus2-s2.0-85213019834
dc.identifier.scopusqualityQ3
dc.identifier.startpage2126
dc.identifier.urihttps://hdl.handle.net/20.500.12662/4743
dc.identifier.volume28
dc.identifier.wosWOS:001407427700026
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherMarmara Univ, Fac Pharmacy
dc.relation.ispartofJournal of Research in Pharmacy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250310
dc.subjectAronia melanocarpa
dc.subjectpremature ovarian failure
dc.subjectcyclophosphamide
dc.subjectVEGF
dc.subjectapoptosis.
dc.titleThe therapeutic role of Aronia melanocarpa on cyclophosphamide-induced premature ovarian failure
dc.typeArticle

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