Thyroid function in healthy and unhealthy preterm newborns

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dc.contributor.authorKorkmaz, Gokten
dc.contributor.authorOzcetin, Mustafa
dc.contributor.authorCag, Yakup
dc.contributor.authorYukselmis, Ufuk
dc.contributor.authorOngel, Volkan
dc.contributor.authorIsik, Olcay
dc.date.accessioned2024-03-13T10:33:20Z
dc.date.available2024-03-13T10:33:20Z
dc.date.issued2018
dc.departmentİstanbul Beykent Üniversitesien_US
dc.description.abstractBackground: The thyroid gland and hormonal regulation are among the most important systems to be investigated in pre-term infants. This study sought to investigate thyroid hormone levels of healthy and unhealthy pre-term infants. Methods: The prospective study included 53 consecutive premature infants admitted to the neonatal intensive care unit within a duration of one year. Of these preterm babies, 20 were healthy, while 33 had problems such as asphyxia or RDS. Venous blood samples were collected at baseline 0-24 hours, 7 and 14 days and FT3, FT4, and TSH levels were determined. Other data recorded included demographic characteristics of the patients and clinical variables. Results: The most frequent health problems were RDS (87.9%), sepsis (30.3%), and retinopathy of prematurity (24.2%). The mean TSH levels showed a consistent decline at three consequent measurements in both groups, which were always significantly lower in unhealthy pre-terms. In both groups, TSH levels showed significant decreases on Day 7 and Day 14 compared to the baseline levels (p<005). The levels of FT3 and FT4 consistently showed significant correlations with gestational week and birth weight at each of the three measurements. Conclusion: Pre-term infants, especially those having problems, have significant hypothyroxinemia that may require thyroid hormone replacement therapy.en_US
dc.identifier.doi10.4314/ahs.v18i2.23
dc.identifier.endpage383en_US
dc.identifier.issn1680-6905
dc.identifier.issn1729-0503
dc.identifier.issue2en_US
dc.identifier.pmid30602965en_US
dc.identifier.scopus2-s2.0-85049132108en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage378en_US
dc.identifier.urihttps://doi.org/10.4314/ahs.v18i2.23
dc.identifier.urihttps://hdl.handle.net/20.500.12662/3906
dc.identifier.volume18en_US
dc.identifier.wosWOS:000436373700023en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMakerere Univ, Fac Meden_US
dc.relation.ispartofAfrican Health Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPrematurityen_US
dc.subjecthypothyroxinemiaen_US
dc.subjectthyroiden_US
dc.subjectTSHen_US
dc.titleThyroid function in healthy and unhealthy preterm newbornsen_US
dc.typeArticleen_US

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