EVALUATION OF ZINC AND COPPER TOXICITY CAUSED BY INGESTION OF TURKISH COINS: AN IN VITRO STUDY

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dc.contributor.authorAlkan, Fatma Ates
dc.contributor.authorKilinc, Evren
dc.contributor.authorGulyasar, Tevfik
dc.contributor.authorOr, Mehmet Erman
dc.date.accessioned2024-03-13T10:33:28Z
dc.date.available2024-03-13T10:33:28Z
dc.date.issued2020
dc.departmentİstanbul Beykent Üniversitesien_US
dc.description.abstractCoins are foreign objects that are commonly ingested by children and pets due to their shiny appearance and bright colors. The current study investigated whether Turkish coins can lead to zinc (Zn) and copper (Cu) toxicity as a result of exposure to simulated gastric juice (i.e. hydrochloric acid solution simulating the gastric environment). Five groups of coins were exposed to simulated gastric juice (0.15 N, pH:1-2) for a period of 4 (Group 1), 12 (Group 2), 24 (Group 3), 48 (Group 4), 72 (Group 5) and 120 h (Group 5) at body temp. (37 degrees C). Zinc and copper levels were determined in the gastric acid solution by using an inductively coupled plasma optical emission spectrophotometer (ICP-OES). The coins were also evaluated for corrosive damage and weight loss. Group 5 had statistically higher Cu and Zn levels versus the other groups. However, at body temp. (37 degrees C), copper and zinc levels increased steadily in parallel to the duration for which the coin remained in the stomach after ingestion. After 120-hour exposure at 37 degrees C, all coins had various types of damage compared to the baseline, such as color alteration, erosion, and visible surface cavities. The mechanisms relating to local and systemic copper and zinc toxicity caused by coin ingestion is yet to be clarified for both Turkish and international coins. Therefore, it can be foreseen that intervention is required in the first 24 h after ingesting 5 kurus coins and, unless removed spontaneously in 48 h, such intervention is needed for the other coins.en_US
dc.identifier.doi10.5601/jelem.2020.25.1.1959
dc.identifier.endpage971en_US
dc.identifier.issn1644-2296
dc.identifier.issue3en_US
dc.identifier.startpage961en_US
dc.identifier.urihttps://doi.org/10.5601/jelem.2020.25.1.1959
dc.identifier.urihttps://hdl.handle.net/20.500.12662/3957
dc.identifier.volume25en_US
dc.identifier.wosWOS:000538157700010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherPolish Society Magnesium Researchen_US
dc.relation.ispartofJournal Of Elementologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTurkish coinsen_US
dc.subjectchildrenen_US
dc.subjectzincen_US
dc.subjectcopperen_US
dc.subjecttoxicityen_US
dc.titleEVALUATION OF ZINC AND COPPER TOXICITY CAUSED BY INGESTION OF TURKISH COINS: AN IN VITRO STUDYen_US
dc.typeArticleen_US

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