Level of trace elements in serum and toenail samples of patients with onychocryptosis (ingrown toenail) and onychomycosis

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dc.contributor.authorKilinc, Evren
dc.contributor.authorButurak, Birce
dc.contributor.authorAlkan, Fatma Ates
dc.date.accessioned2024-03-13T10:35:01Z
dc.date.available2024-03-13T10:35:01Z
dc.date.issued2020
dc.departmentİstanbul Beykent Üniversitesien_US
dc.description.abstractBackground: Onychocryptosis (ingrown toenail) and onychomycosis are common pathologies of the toenail and affecting many people. Since levels of trace elements have been shown to vary in certain diseases, in the presented work, chromium (Cr), copper (Cu), iron (Fe), magnesium (Mg), manganese (Mn), selenium (Se), and zinc (Zn) levels of toenail and serum samples of healthy individuals and patients with onychocryptosis and onychomycosis were compared. Methods: Serum and toenail samples of 88 voluntary subjects (healthy n = 24; onychomycosis n = 24; onychocryptosis n = 40) aged between 19-80 years were collected. Levels of trace elements in the samples were analyzed by using an inductively coupled plasma-optical emission spectrophotometer (ICP-OES Thermo iCAP-6000). The differences in medians between the groups for elements were evaluated with Kruskal -Wallis H test with post hoc for pairwise comparisons in SPSS 18. Results: Mg (p < 0.001) and Mn (p = 0.002) levels were significantly increased whereas Zn (p = 0.011) level was decreased in toenails of patients with onychomycosis compared to healthy subjects. Although Mg and Mn levels were higher in female subjects with onychomycosis (p = 0.001; p = 0.019), Mn was only increased in male subjects (p = 0.015). Mg was the only trace element found to be independent of sex, age, and smoking status in patients with onychomycosis. However, no significant difference has been found in serum trace element levels neither between any groups nor toenail trace element levels of patients with onychocryptosis and healthy subjects. Conclusion: As a response of the human body to pathogens like fungi in toenails, Mg, Mn and Zn levels vary. Especially the role of Mg ions in onychomycosis needs to be investigated more specifically.en_US
dc.identifier.doi10.1016/j.jtemb.2020.126509
dc.identifier.issn0946-672X
dc.identifier.pmid32302924en_US
dc.identifier.urihttps://doi.org/10.1016/j.jtemb.2020.126509
dc.identifier.urihttps://hdl.handle.net/20.500.12662/4214
dc.identifier.volume61en_US
dc.identifier.wosWOS:000543366700009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Gmbhen_US
dc.relation.ispartofJournal Of Trace Elements In Medicine And Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOnychocryptosisen_US
dc.subjectOnychomycosisen_US
dc.subjectTrace elementsen_US
dc.subjectToenailsen_US
dc.subjectserumen_US
dc.subjectMagnesiumen_US
dc.titleLevel of trace elements in serum and toenail samples of patients with onychocryptosis (ingrown toenail) and onychomycosisen_US
dc.typeArticleen_US

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