One-pot Multicomponent Reaction: An Efficient Synthesis of 4-(Het)Aryl-substituted Pyrazolo-quinolinones

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dc.contributor.authorBeker, Hueseyin Kerim
dc.contributor.authorKaban, Seniz
dc.date.accessioned2025-03-09T10:48:39Z
dc.date.available2025-03-09T10:48:39Z
dc.date.issued2024
dc.departmentİstanbul Beykent Üniversitesi
dc.description.abstractIntroduction Pyrazolo-quinolinones (PQs) are a versatile class of Organic chemistry and it was found that they have very advanced functionally promising as selective compounds due to their scaffold and demonstrated low toxicity and considerable clinical promise. Moreover, these compounds have an important role in different applications such as analytical reagents, technical, pharmaceutical development, and biological markers. So, we aimed to synthesize and characterize new 4-(Het)aryl-substituted Pyrazole-quinolinones.Methods Synthesis of One-Pot Multicomponent Reaction was carried out with the reaction of 5-amino-3-methyl-1H-pyrazole 1a, and 5-amino-3-phenyl-1H-pyrazole 1b and dimedone 2 with some (het)aryl aldehydes 3 using ethanol. Characterizations such as the linear structures and the regiospecificity of the reactions were determined by using NMR, GC-MS, IR, and UV measurements.Results and Conclusion This research will be very useful for all methods and procedures using multi one-point reactions which are very popular in the synthesis of heterocyclic systems for pyrazole- quinoline skeleton synthesis.
dc.identifier.doi10.2174/1570179421666230821102745
dc.identifier.endpage297
dc.identifier.issn1570-1794
dc.identifier.issn1875-6271
dc.identifier.issue3
dc.identifier.pmid37605395
dc.identifier.scopus2-s2.0-85187123827
dc.identifier.scopusqualityQ3
dc.identifier.startpage292
dc.identifier.urihttps://doi.org/10.2174/1570179421666230821102745
dc.identifier.urihttps://hdl.handle.net/20.500.12662/4633
dc.identifier.volume21
dc.identifier.wosWOS:001200782900005
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBentham Science Publ Ltd
dc.relation.ispartofCurrent Organic Synthesis
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250310
dc.subjectRegiospecific pyrazole cyclo-condensation
dc.subject(het)aryl aldehyde
dc.subjectmulticomponent reaction
dc.subjectpyrazolo[3,4-b]quinoline
dc.subjectorganic chemistry
dc.subjectheterocyclic compound
dc.titleOne-pot Multicomponent Reaction: An Efficient Synthesis of 4-(Het)Aryl-substituted Pyrazolo-quinolinones
dc.typeArticle

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