The Role of Endoplasmic Reticulum Stress in Gastroesophageal Reflux Disease Symptoms and Treatment

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dc.contributor.authorKasap, Elmas
dc.contributor.authorBuran, Tahir
dc.contributor.authorAvcu, Aysun Toraman
dc.contributor.authorHasdemir, Pinar Solmaz
dc.contributor.authorBalcan, Erdal
dc.contributor.authorAktan, Cagdas
dc.contributor.authorKorkmaz, Mehmet
dc.date.accessioned2024-03-13T10:33:24Z
dc.date.available2024-03-13T10:33:24Z
dc.date.issued2023
dc.departmentİstanbul Beykent Üniversitesien_US
dc.description.abstractBackground: Gastroesophageal reflux disease is a common condition worldwide. There is no curative treatment for gastroesophageal reflux disease. Endoplasmic reticulum stress leads to the activation of the unfolded protein response and has an important role in inflammation. The aim is to determine the role of endoplasmic reticulum stress in the follow-up of individuals with gastroesophageal reflux disease and the temporal changes of endoplasmic reticulum stress markers with treatment. Methods: Twenty-four subjects in total were recruited prospectively, of whom 15 had nonerosive reflux disease. Two biopsies from 2 cm above the esophagogastric junction, 2 biopsies from gastric antrum mucosa, and 2 biopsies from gastric corpus mucosa were taken. Simultaneously, 2 tubes of venous blood samples were drawn from each individual (1 tube for studying the genetic markers and 1 tube for analyzing the CYP2C19 polymorphism). Results: The mean age was 42.3 +/- 17.6 for women and 34.66 +/- 11.2 for men. Pantoprazole, esomeprazole, rabeprazole, and lansoprazole preparations were used for treatment. There was no significant difference between tissue and blood samples for panel genes ATF-6, XBP-1, DDIT-3, DNAJC-10, and EIF-2-AK before treatment. There was a significant decrease in the level of ATF-6, XBP-1, DNAJC-9, EIF2-AK, and NF-2L-2 genes in blood after treatment. In the comparison of proton pump inhibitors, significant decreases in the expression of the ATF-6, XBP-1, and DNAJC-9 mRNAs were detected in blood from individuals after treatment. Conclusion: Endoplasmic reticulum stress can be for evaluating the clinical improvement and the effectiveness of treatment in gastroesophageal reflux disease.en_US
dc.description.sponsorshipTurkish Society of Gastroenterology (TGD) [25/12/2017 161]en_US
dc.description.sponsorshipResearch reported in this manuscript was supported by the Turkish Society of Gastroenterology (TGD), (25/12/2017 161) Ankara/Turkey.en_US
dc.identifier.doi10.5152/tjg.2023.21282
dc.identifier.endpage541en_US
dc.identifier.issn2148-5607
dc.identifier.issue5en_US
dc.identifier.pmid37158535en_US
dc.identifier.scopus2-s2.0-85158083697en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage533en_US
dc.identifier.trdizinid1178162en_US
dc.identifier.urihttps://doi.org/10.5152/tjg.2023.21282
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1178162
dc.identifier.urihttps://hdl.handle.net/20.500.12662/3935
dc.identifier.volume34en_US
dc.identifier.wosWOS:001066591900012en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAvesen_US
dc.relation.ispartofTurkish Journal Of Gastroenterologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEndoplasmic reticulum stressen_US
dc.subjectGERDen_US
dc.subjectheartburnen_US
dc.subjectproton pump inhibitorsen_US
dc.subjectregurgitationen_US
dc.titleThe Role of Endoplasmic Reticulum Stress in Gastroesophageal Reflux Disease Symptoms and Treatmenten_US
dc.typeArticleen_US

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