Investigation of Patients With Eye Closure Sensitive Epilepsy With Magnetic Resonance Spectroscopy

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dc.contributor.authorYildirim, Feyza
dc.contributor.authorAydin, Zeynep
dc.contributor.authorSakci, Zakir
dc.contributor.authorYalcin, Ayse Destina
dc.date.accessioned2024-03-13T10:33:00Z
dc.date.available2024-03-13T10:33:00Z
dc.date.issued2022
dc.departmentİstanbul Beykent Üniversitesien_US
dc.description.abstractIntroduction and aim: A proportion of patients diagnosed with genetic generalized epilepsy (GGE) experience eye-closure sensitivity (ECS), the underlying pathogenesis of which is unknown. In this study, we compare magnetic resonance spectroscopy (MRS) findings of healthy volunteers with patients diagnosed with GGE, with and without ECS, to detect possible explanatory differences between groups. Materials and methods: A total of 33 patients diagnosed with GGE: 17 with ECS and 16 without, and 12 healthy volunteers are included. MRS measurements of N-acetyl-aspartate (NAA), choline (Cho), and creatine (Cr) were made of bilateral occipital lobes and thalamus, and values of patients with GGE were compared with those of normal controls, and within subgroups with different clinical variables, using appropriate statistical tests. Results: Left occipital NAA and NAA/Cr levels were found to be significantly higher in the ECS group than in the control group. In the ECS epilepsy group, a significant moderate positive correlation was noted between left thalamic Cr and duration of drug therapy (r = .539, P = .047) and left thalamic Cr and age at epilepsy onset (r = .564, P = .036). Additionally, left thalamic NAA and NAA/Cr levels were observed to be lower in GGE patients compared to healthy subjects, although not to a statistically significant degree. Conclusion:The differences in MRS-measurable metabolites in the left occipital lobe in those with ECS epilepsy suggest an association between the ECS mechanism and the left occipital lobe. Our results also support the multifocal thalamocortical pathway disorder in the pathophysiology of GGE based on the observation of cellular dysfunction in the thalamus.en_US
dc.identifier.doi10.1177/15500594211040953
dc.identifier.endpage53en_US
dc.identifier.issn1550-0594
dc.identifier.issn2169-5202
dc.identifier.issue1en_US
dc.identifier.pmid34558322en_US
dc.identifier.scopus2-s2.0-85115729423en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage45en_US
dc.identifier.urihttps://doi.org/10.1177/15500594211040953
dc.identifier.urihttps://hdl.handle.net/20.500.12662/3727
dc.identifier.volume53en_US
dc.identifier.wosWOS:000702388300001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofClinical Eeg And Neuroscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectmagnetic resonance spectroscopyen_US
dc.subjectepilepsyen_US
dc.subjecteye-closure sensitivityen_US
dc.subjectoccipital lobeen_US
dc.subjectthalamusen_US
dc.titleInvestigation of Patients With Eye Closure Sensitive Epilepsy With Magnetic Resonance Spectroscopyen_US
dc.typeArticleen_US

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