Separation of Penicillin G from Fermentation Broth Using N,N-Dioctyloctan-1-amine Extractant in Different Diluents

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dc.contributor.authorUslu, Hasan
dc.contributor.authorGunyeli, Seyhan
dc.contributor.authorIlbay, Zeynep
dc.contributor.authorKirbaslar, S. Ismail
dc.date.accessioned2024-03-13T10:35:21Z
dc.date.available2024-03-13T10:35:21Z
dc.date.issued2015
dc.departmentİstanbul Beykent Üniversitesien_US
dc.description.abstractThe extraction of penicillin G was investigated using N,N-Dioctyloctan-1-amine (TOA) with different diluents having distinct functional groups. Nine diluents were used in the study, namely, octan-1-ol, nonan-1-ol, isoamyl alcohol, ethyl ethanoate, propyl ethanoate, methyl iso butyl ketone(MIBK), octan-2-one, octane, and decane. The measurements were performed at a temperature of 298.2 K. The experimental results of batch extractions were used to calculate distribution coefficients (K-D), loading factors (Z), and extraction efficiency (E). The highest distribution coefficient (K-D = 5.79) was obtained with isoamyl alcohol, and its extraction efficiency was 85.27%. Further, the highest loading factor was reached to a value of 0.130 at 0.374 mol.kg(-1) amine concentration. Overloading was not observed at any amine concentration. Solvatochromic model (Linear solvation Energy Relationship (LSER)) for data which obtained from alcohols experiments gives the good results as near as same to experimental results. Suitability of data between experiments and model predictions have been tested with root main square deviation (RMSD) with 0.99.en_US
dc.identifier.doi10.1080/01496395.2014.967408
dc.identifier.endpage1359en_US
dc.identifier.issn0149-6395
dc.identifier.issn1520-5754
dc.identifier.issue9en_US
dc.identifier.scopus2-s2.0-84930167389en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1353en_US
dc.identifier.urihttps://doi.org/10.1080/01496395.2014.967408
dc.identifier.urihttps://hdl.handle.net/20.500.12662/4383
dc.identifier.volume50en_US
dc.identifier.wosWOS:000355260300008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofSeparation Science And Technologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTOAen_US
dc.subjectpenicillin Gen_US
dc.subjectreactive extractionen_US
dc.subjectisoamyl alcoholen_US
dc.titleSeparation of Penicillin G from Fermentation Broth Using N,N-Dioctyloctan-1-amine Extractant in Different Diluentsen_US
dc.typeArticleen_US

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