Oxidative stress markers and trace element levels in patients with hip fracture

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dc.contributor.authorMert, Murat
dc.contributor.authorHocaoglu-Emre, Fatma S.
dc.contributor.authorErdogan, Sinan
dc.contributor.authorBahtiyar, Nurten
dc.date.accessioned2024-03-13T10:33:27Z
dc.date.available2024-03-13T10:33:27Z
dc.date.issued2020
dc.departmentİstanbul Beykent Üniversitesien_US
dc.description.abstractIntroduction: Osteoporosis is a condition causing bone resorption and hip fractures (HF) in the elderly. Oxidative stress (OS) plays a role in the pathogenesis of osteoporosis. Levels of the trace elements copper (Cu), selenium (Se), and zinc (Zn) have been shown to affect bone structure, and are cofactors of the enzymes of bone metabolism. Materials and methods: Red blood cell (RBC) levels of malondialdehyde (MDA) and reduced glutathione (GSH) as well as plasma levels of Cu, Se, and Zn were measured preoperatively and on the second day after the surgery in 51 HF patients. The levels of these analytes were compared with 51 age-matched healthy controls. The levels of these OS parameters and trace elements were compared according to survival status. Results: Significantly higher MDA levels, as an indicator of lipid peroxidation, were seen in the patient group on the preoperative and second days after the surgery (p = 0.05: p < 0.001, respectively). The GSH levels were lower preoperatively and on the second day after the surgery compared to the baseline (p < 0.0001; p < 0.0001. respectively). Se and Zn levels were lower in the postoperative period as compared to the preoperative period (p = 0.04; p < 0.0001, respectively). The overall mortality of our study group within 2 years was 35.3%. Preoperative Cu levels were found to be significantly higher in the surviving HF patients. Conclusion: We demonstrated an association between OS markers and HF in our study group. We also suggest that deteriorated trace element status in the HF patients is related to the occurrence of HF incidents, and might be related to the mortality following HF surgery.en_US
dc.identifier.doi10.5414/TEX01602
dc.identifier.endpage74en_US
dc.identifier.issn0946-2104
dc.identifier.issue2en_US
dc.identifier.startpage68en_US
dc.identifier.urihttps://doi.org/10.5414/TEX01602
dc.identifier.urihttps://hdl.handle.net/20.500.12662/3947
dc.identifier.volume37en_US
dc.identifier.wosWOS:000539395900004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherDustri-Verlag Dr Karl Feistleen_US
dc.relation.ispartofTrace Elements And Electrolytesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMDAen_US
dc.subjectGSHen_US
dc.subjecthip fractureen_US
dc.subjectoxidative stressen_US
dc.subjecttrace elementsen_US
dc.titleOxidative stress markers and trace element levels in patients with hip fractureen_US
dc.typeArticleen_US

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